Protein Alignment CG5522 and Sos1

DIOPT Version :9

• Sequence 1: NP_725613.1
• Gene: CG5522 / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001094186.1
• Gene: Sos1 / 313845
• RGDID: 1310949
• Length: 1319
• Species: Rattus norvegicus
• Alignment Length: 598
• Identity: 129/598 - (21%)
• Similarity: 230/598 - (38%)
• Gaps: 148/598 - (24%)

  Fly   100 SKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALR 164
            :|.:..|...|.|..|...:|.:||  |...:.|           |.|.|  |:..|.:.|..:.
  Rat   734 TKIIQRKKIARDNGPGHNITFQNSP--PTVEWHI-----------SRPGH--IETFDLLTLHPIE 783

  Fly   165 VPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAE 229
            :     |.|:|||:..::..:||.||....|||:||.:|:||::...:...:.:.|..:.|:..|
  Rat   784 I-----ARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETE 843

  Fly   230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIF 294
            ..::|..:::..|::.:...||||.:.:..::|||.|:.:|||..|:..:..:.:...:...::
  Rat   844 NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL- 907

  Fly   295 SDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHP-----HKGGLEPEQRRNKMNNILRVI 354
             .:|::....:.|.|:..||:|:.|::||:::..:..:|     |...|....:|.::..|...|
  Rat   908 -SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGEI 971

  Fly   355 SNYQQSNYKHLQKHEATQKYLTSIRYIEEL-------QNIFEEDQYKRSLNLEPASPSG----PS 408
            ..||  |..:..:.|:..|     |:.|.|       :..|.:..:.:||.:||.:|..    |
  Rat   972 QQYQ--NQPYCLRVESDIK-----RFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFP- 1028

  Fly   409 SSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFA 473
                   :.::..:.:|.:...|..|    |:||..:..:..|         .|...|.:|.:..
  Rat  1029 -------KKYSYPLKSPGVRPSNPRP----GTMRHPTPLQQEP---------RKISYSRIPESET 1073

  Fly   474 EKCQCC-----IVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGH-------------------- 513
            |.....     ..:..|...:.|:....| .:|.  :.|:.|..|
  Rat  1074 ESTASAPNSPRTPLTPPPASSASSNTDVC-SVFD--SDHSASPFHSRSASVSSISLSKGTEEVPV 1135

  Fly   514 ---------PHHLHLELDPSQVQPRHHLLDD---------SVLEHSDALSQADLTSLESAEGIMC 560
                     |.....|..||::..:|  ||.         :...:|...|.:|.||:
  Rat  1136 PPPVPPRRRPESAPAESSPSKIMSKH--LDSPPAIPPRQPTSKAYSPRYSISDRTSI-------- 1190

  Fly   561 DFTGSDCDLMSPEAAAAMHGCVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERN 625
                ||    .||:...:   ..|:.|    |.|.|.|.....||         ||...|.|:..
  Rat  1191 ----SD----PPESPPLL---PPREPV----RTPDVFSSSPLHLQ---------PPPLGKKSDHG 1231

  Fly   626 D--FKREPCKVCP 636
            :  |...|....|
  Rat  1232 NAFFPNSPSPFTP 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	60/248 (24%)
		PH_RalGPS1_2	578..692	CDD:270120	15/61 (25%)
		PH	578..685	CDD:278594	15/61 (25%)
Sos1	NP_001094186.1	H2A	97..177	CDD:305064
		RhoGEF	204..389	CDD:214619
		PH_SOS	439..545	CDD:269963
		PH	445..546	CDD:278594
		RasGEFN	597..741	CDD:214571	1/6 (17%)
		RasGEF	776..1015	CDD:238087	60/252 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810