DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and Rasgef1a

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_232315.7	Gene:	Rasgef1a / 312664	RGDID:	1305836	Length:	489	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	98/428 - (22%)
Similarity:	153/428 - (35%)	Gaps:	73/428 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PTTDYNGYTGQAYAATQFKQSSPPPPPSQ----------QQQQPTRVSKQRSPNTNGSAHTMACL 79
            ||.||  |..:.|..|....|....||..          :|:|......:::...:.|...:..|
  Rat    67 PTVDY--YPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLL 129

  Fly    80 RQ-----------EKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTI 133
            ::           ||...|.:    ::..:.::......|.:|.....:.|...|..:......:
  Rat   130 KEWTEAFPYDFQDEKAMAELK----AIAHRVTQCDEENGTVKKAITQMIQSLLLSLAARSQLQEL 190

  Fly   134 AASAAPP--SKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCA-- 194
            ......|  .|...|.|.....|.|  ||.....|. |||.|:|.::......|:|::|....
  Rat   191 REKLRSPVVDKGPVLKAKPPAAQKD--ILGVCSDPL-VLAQQLTHIELERVNSIRPEDLMQIISH 252

  Fly   195 WTKKDKH------VNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNN 253
            ....|.|      ..|.::.|:...||..|.....|:....:.|.|..::..||.||::...:.|
  Rat   253 MDSLDNHRCRGDMTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGN 317

  Fly   254 LHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLE---------- 308
            .:|:.||||.|..:.:.||.|||   ||.....||.|........|:.|.|:.|:
  Rat   318 FNSMMAIISGMNLSPVARLKKTW---SKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTAN 379

  Fly   309 -SLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEPEQRRN--KMNNILRVISNYQQSNYKH--LQKH 368
             |.....||...||:.|:.::...|.:.   .|....|  |...|.|.|..:.......  .:|.
  Rat   380 SSREKIVIPVFNLFVKDIYFLHKIHTNH---LPSGHINFKKFWEISRQIHEFMTWTRVECPFEKD 441

  Fly   369 EATQKY-LTSIRYIEEL-----------QNIFEEDQYK 394
            :..|.| ||:..|.||.           :|..|:|.:|
  Rat   442 KKIQSYLLTAPIYSEEALFIASFESEGPENHMEKDSWK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	69/267 (26%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgef1a	XP_232315.7	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910