Protein Alignment RalGPS and Ralgps2

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001388325.1
• Gene: Ralgps2 / 304887
• RGDID: 1311537
• Length: 583
• Species: Rattus norvegicus
• Alignment Length: 638
• Identity: 241/638 - (37%)
• Similarity: 324/638 - (50%)
• Gaps: 152/638 - (23%)

  Fly   141 SKSQSLPAHAS--IKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVN 203
            |.|:||....|  .|..|||:...|:|..:..|.||||:|.|||..|||||||||.|.||:|:.:
  Rat    22 SSSESLSEKGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSS 86

  Fly   204 TPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSAS 268
            .||.||||:||||.|||.|:|||:|:..|.|||:::|:||.||||:||||||:|.|::|.:|||.
  Rat    87 APNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAP 151

  Fly   269 IYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRL-PCIPYLGLFLTDLIYIDLAH 332
            |:|||||||.||:||:..|::|..:.|.:||:..||.|:.||:: |||||||::|:||.|||.|:
  Rat   152 IFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAY 216

  Fly   333 PHKGG-LEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRS 396
            |..|. ||.|||.|.||||||:||:.|||....:......||||.|::||||||...|:|.||.|
  Rat   217 PSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLS 281

  Fly   397 LNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVP---------- 451
            |.:||.: |.|.|:  :|:|    ::..|.:|.   ||..  |....|:....:|
  Rat   282 LKIEPGA-STPRSA--ASRE----DLAGPDVGA---SPQG--GRKSSAAEGALLPQTPPSPRHLI 334

  Fly   452 --GHRKCRSLG---------TKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIA 505
              |||||.|||         .:|:|::.|
  Rat   335 PHGHRKCHSLGYNFIHKMNTAEFKSATFP------------------------------------ 363

  Fly   506 THNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLE-HSDALSQADLTSLESAEGIMCDFTGSDCDL 569
                               ...|| |||||||:| |:.:..||:.::|.|...|    ..||...
  Rat   364 -------------------NAGPR-HLLDDSVMEPHAPSRGQAESSTLSSGISI----GSSDGSE 404

  Fly   570 MSPE-----------------------------------------------AAAAMHGCVRRKTV 587
            :|.|                                               .|..:.|.:||||:
  Rat   405 LSEETSWPAFERNRLYHSLGPVTRMPRNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTL 469

  Fly   588 QKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVSDNTKHKN 652
            .|||:||.||||.:||..:....|.|:|.||.|.:||..||....|...:.||...::|:.:|.:
  Rat   470 LKEGKKPTVASWTKYWAALCGTQLFYYPAKSLKATERKHFKSTSNKNVSVVGWMVMMADDPEHPD 534

  Fly   653 TFELCHRTLGTVYRFRTDSPQMTHLW---SNAICKLATMRVPKPLPTNLMSFE 702
            .|.|.....|..|:|:..|.....||   .:|.|:....:|    |||||:||
  Rat   535 LFLLTDSEKGNSYKFQAGSRMNAMLWFKHLSAACQSNRQQV----PTNLMTFE 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	100/166 (60%)
		PH_RalGPS1_2	578..692	CDD:270120	42/116 (36%)
Ralgps2	NP_001388325.1	RasGEF	45..286	CDD:214539	137/240 (57%)
		PH_RalGPS1_2	459..574	CDD:270120	41/114 (36%)