DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and RASGRP3

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001132960.1	Gene:	RASGRP3 / 25780	HGNCID:	14545	Length:	690	Species:	Homo sapiens

Alignment Length:	288	Identity:	82/288 - (28%)
Similarity:	128/288 - (44%)	Gaps:	56/288 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LANQITLLDFPVFAQIQPDELSSCAWTKKDKHV------NTPNIVAFTKRFNHTSFWTVQEILNA 228
            ||..:|.|:...|.:|        ::|....:|      |.|.:......||..|.|....:|:.
Human   156 LAEHLTFLEHKSFRRI--------SFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSK 212

  Fly   229 EQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDI 293
            ..|:||||:||.||.|||||.:|.|.::|.|::..:..:||.||.:|.:.||.:....::.::::
Human   213 PTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTEL 277

  Fly   294 FSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEPEQRRNKMNNILRVISNYQ 358
            .|...|:.|.|..........||.||:.|.|||.:.:..|      .....||:|    ::..:|
Human   278 VSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFP------DWTEENKVN----IVKMHQ 332

  Fly   359 QSNYKHLQKHEATQKYLTSIR----YIE---ELQNIF---------EEDQYKRSLNLEPA-SPSG 406
            .|         .|...|.|::    ::|   :|.|:.         |:|.||.||.|||. |.|.
Human   333 LS---------VTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388

  Fly   407 PSSSSCSSKESFNVEVVTPALGCLNLSP 434
            |:|.:..:|.      |.|....|.:.|
Human   389 PTSPTTPNKP------VVPLEWALGVMP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	70/251 (28%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
RASGRP3	NP_001132960.1	REM	11..126	CDD:100121
		RasGEF	148..384	CDD:214539	73/254 (29%)
		EF-hand_7	428..478	CDD:316058
		C1	495..544	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810