DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and efc25

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_596123.1	Gene:	efc25 / 2540248	PomBaseID:	SPBC336.03	Length:	987	Species:	Schizosaccharomyces pombe

Alignment Length:	271	Identity:	78/271 - (28%)
Similarity:	135/271 - (49%)	Gaps:	18/271 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 PPSKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVN 203
            |.|.:|.|   .|......:.|:......:..|:|:|||:|....||...|....:|..:|....
pombe   728 PDSLTQRL---LSSPMATFISLNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRDSRSA 789

  Fly   204 TPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSAS 268
            ..|.:.|:..|   ::|.:..||..:..|.|..:|:.||:.|.|...|.|..:|.:|:||:.||.
pombe   790 VRNYINFSNCF---TYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAP 851

  Fly   269 IYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHP 333
            ||||...:..:..:|......|.:|...:.|::..|:.|....|||:|:||:.|:||.:||..:|
pombe   852 IYRLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKAELPCVPFLGVILSDLTFIDEGNP 916

  Fly   334 HKGGLEPE----QRRNKMNNILRVISNYQQSNYKHLQKHEATQKY-LTSIRYI-EELQNIFEEDQ 392
            ......|.    .:|:::.:::..:..:|.|:|: :|.:...|.| |...|:: ::|..:|:
pombe   917 DVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYE-MQSNTDLQSYILHRCRFVNQDLSYLFD--- 977

  Fly   393 YKRSLNLEPAS 403
              :||:|||.|
pombe   978 --KSLSLEPRS 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	68/242 (28%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
efc25	NP_596123.1	RasGEF_N	593..700	CDD:279012
efc25	NP_596123.1	RasGEF	755..932	CDD:279011	55/179 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47356
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910