DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and ste6

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_588316.1	Gene:	ste6 / 2538724	PomBaseID:	SPCC1442.01	Length:	911	Species:	Schizosaccharomyces pombe

Alignment Length:	261	Identity:	79/261 - (30%)
Similarity:	130/261 - (49%)	Gaps:	49/261 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 LRVPADVLANQITLLDFPVFAQIQPDELSSCAW------TKKDKHVNTPNIVAFTKRF---NHTS 218
            |.:|...:|.|:.:|:|..|:.|...:..:..|      :.|:|          |..|   ||..
pombe   660 LLLPPREIAKQLCILEFQSFSHISRIQFLTKIWDNLNRFSPKEK----------TSTFYLSNHLV 714

  Fly   219 FWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKD 283
            .:..:.|:..|:|::|..::.:||:|...|.||||..|||:||||:.|:.|:||.||||.|:.|.
pombe   715 NFVTETIVQEEEPRRRTNVLAYFIQVCDYLRELNNFASLFSIISALNSSPIHRLRKTWANLNSKT 779

  Fly   284 RNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEPE------- 341
            ..:|:.|:::...:.|::|.|..||:..|||:|:||::.|||.::      |.|.:..
pombe   780 LASFELLNNLTEARKNFSNYRDCLENCVLPCVPFLGVYFTDLTFL------KTGNKDNFQNMINF 838

  Fly   342 QRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQN-IFEEDQ-----YKRSLNLE 400
            .:|.|:..||..|..:|...|           ....|..::||.| :...::     |:|||.:|
pombe   839 DKRTKVTRILNEIKKFQSVGY-----------MFNPINEVQELLNEVISRERNTNNIYQRSLTVE 892

  Fly   401 P 401
            |
pombe   893 P 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	77/258 (30%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
ste6	NP_588316.1	SH3	7..55	CDD:214620
		RasGEFN	489..604	CDD:214571
		RasGEF	659..895	CDD:214539	79/261 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1628
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003356
OrthoInspector	1	1.000	-	-		otm47356
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910