DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5522 and Ralgps1

DIOPT Version :9

Sequence 1:NP_725613.1 Gene:CG5522 / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_780420.1 Gene:Ralgps1 / 241308 MGIID:1922008 Length:585 Species:Mus musculus


Alignment Length:645 Identity:245/645 - (37%)
Similarity:339/645 - (52%) Gaps:135/645 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 GCYYTIAASAAPP---SKSQSLPAHA---SIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQ 186
            |...::..::|.|   |.|.||...:   :.|..|||:...|:|..:..|:||||:|.|||..||
Mouse     6 GLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQ 70

  Fly   187 PDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHEL 251
            |:||:||.|:||:||...||:||||:|||..|||.|:|||.|:..|.||||::||:|:||||.||
Mouse    71 PEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLEL 135

  Fly   252 NNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRL-PCI 315
            ||||||.:::||:|||.|:|||||||.|::||:..|::|..:.|.:||:...|.|:.||:: |.|
Mouse   136 NNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSI 200

  Fly   316 PYLGLFLTDLIYIDLAHPHKGG-LEPEQRRNKMNNILRVISNYQQS-NYKHLQKHEATQKYLTSI 378
            ||||::|.||||||.|:|..|. :|.|||.|:||||||:|::.|.| :|.||......||||.|:
Mouse   201 PYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSV 265

  Fly   379 RYIEELQNIFEEDQYKRSLNLEPASPS-----------GPSSSSCSSKESFNVEVVTPALGCLNL 432
            |||||||...|:|.||.||.:||.|.|           |||:.|.|::  |......|       
Mouse   266 RYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSSSAR--FRRRPTCP------- 321

  Fly   433 SPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRC 497
             .....||:    .|..||.|||..|||                              :|..|:.
Mouse   322 -DTSVAGSL----PTPPVPRHRKSHSLG------------------------------NNLMCQL 351

  Fly   498 RRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLE---------HSDALSQADLTSLE 553
            ..:..|.||.               ||  :...|||||||||         |:.:.:..:..||.
Mouse   352 SVVESKSATF---------------PS--EKARHLLDDSVLESRSPRRGLTHTSSTAITNGLSLG 399

  Fly   554 SAE----------GI-------------------------MCDFTGSD---CDLMSPEAAAAMHG 580
            |:|          |:                         .|.::.:.   |.:.|......|.|
Mouse   400 SSESSEFSEEMSAGLESRGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVPTMEG 464

  Fly   581 CVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVS 645
            .:||||:.|||||||::||.|||:.:...:|:|:..||.:|::|..:|..|.|...:.||...:.
Mouse   465 PLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLP 529

  Fly   646 DNTKHKNTFELCHRTLGTVYRFRTDSPQMTHLWSNAI---CKLATMRVPKPLPTNLMSFE 702
            |:.:|.:.|:|.:...|.||:|:|.|.....||...:   ||.:..:|    |.||||||
Mouse   530 DDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQV----PANLMSFE 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5522NP_725613.1 RasGEF 163..400 CDD:214539 136/239 (57%)
PH_RalGPS1_2 578..692 CDD:270120 44/116 (38%)
PH 578..685 CDD:278594 42/109 (39%)
Ralgps1NP_780420.1 RasGEF 46..288 CDD:214539 136/241 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..342 17/66 (26%)
PXXP 330..333 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..410 5/31 (16%)
Required for stimulation of nucleotide exchange by RALA. /evidence=ECO:0000250 461..585 49/127 (39%)
PH_RalGPS1_2 461..576 CDD:270120 43/114 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 220 1.000 Domainoid score I2603
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H65163
Inparanoid 1 1.050 373 1.000 Inparanoid score I2087
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49702
OrthoDB 1 1.010 - - D184404at33208
OrthoFinder 1 1.000 - - FOG0003356
OrthoInspector 1 1.000 - - otm43898
orthoMCL 1 0.900 - - OOG6_104897
Panther 1 1.100 - - O PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5234
SonicParanoid 1 1.000 - - X2715
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.870

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