DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and Rasgrp3

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001159965.1	Gene:	Rasgrp3 / 240168	MGIID:	3028579	Length:	691	Species:	Mus musculus

Alignment Length:	269	Identity:	77/269 - (28%)
Similarity:	121/269 - (44%)	Gaps:	50/269 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LANQITLLDFPVFAQIQPDELSSCAWTKKDKHV------NTPNIVAFTKRFNHTSFWTVQEILNA 228
            ||..:|.|:...|.:|        ::|....:|      |.|.:......||..|.|....:|:.
Mouse   156 LAEHLTFLEHKSFRRI--------SFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSK 212

  Fly   229 EQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDI 293
            ...:||||:||.||.||:||.:|.|.::|.|::..:..:||.||..|.:.||.:....::.::::
Mouse   213 PSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTEL 277

  Fly   294 FSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEPEQRRNKMNNILRVISNYQ 358
            .|...|:.|.|..........||.||:.|.|||.:.:..|      .....||:|    |:..:|
Mouse   278 VSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFP------DWMEENKVN----VVKMHQ 332

  Fly   359 QSNYKHLQKHEATQKYLTSIR----YIE---ELQNIF---------EEDQYKRSLNLEPA-SPSG 406
            .|         .|...|.|::    ::|   :|.|:.         |:|.||.||.|||. |.|.
Mouse   333 LS---------VTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388

  Fly   407 PSSSSCSSK 415
            |:|.:..:|
Mouse   389 PTSPTTPNK 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	69/251 (27%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgrp3	NP_001159965.1	REM	11..126	CDD:100121
		RasGEF	148..384	CDD:214539	72/254 (28%)
		EF-hand_7	428..478	CDD:372618
		C1	495..544	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810