DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and Rasgrp4

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_017177648.1	Gene:	Rasgrp4 / 233046	MGIID:	2386851	Length:	717	Species:	Mus musculus

Alignment Length:	490	Identity:	108/490 - (22%)
Similarity:	179/490 - (36%)	Gaps:	99/490 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSL 146
            |..::|.|:|  ::..:...|:..:....:.|:|..:|. .||..||        ..||..|..|
Mouse   138 EAVHQEPQLE--AVISRFWTTVAQEGNMAQRSLGDASSL-LSPGGPG--------PPPPMSSPGL 191

  Fly   147 PAHASIKQL-DAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAF 210
            .....:..| |       .:..:.||..:|.|:|..|..|.|.:|.  .:..:......|.:...
Mouse   192 GKKRKVSLLFD-------HLETEELAQHLTYLEFRSFQAITPQDLR--GYVLQGSVRGCPALEGS 247

  Fly   211 TKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKT 275
            ....|..|.|....:|:...|.|||:::..||:||::||:|.|.::|.|:...:..::|.||..:
Mouse   248 VGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDS 312

  Fly   276 WACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEP 340
            ...||.....|...|:::.|..:|:|:.|..........:|.||:.|.||:.:..|||.:   .|
Mouse   313 HVHLSPDSTKALLELTELLSSHNNYAHYRRTWAGCTGFRLPVLGVHLKDLVSLYEAHPDR---LP 374

  Fly   341 EQRRN--KMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIF---------EEDQYK 394
            :.|.:  |:|::           |..||:..|.|.........|:|.::.         |::.|:
Mouse   375 DGRLHLPKLNSL-----------YLRLQELMALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 428

  Fly   395 RSLNLEPASPSG-------------------------------------------PSSSSCSSKE 416
            .|...||..|..                                           |......|.|
Mouse   429 LSYAREPRCPKSLPPSPFKAPVVVEWAQGVTPKPDSVTLGQHVEQLVESVFKNYDPEGRGSISLE 493

  Fly   417 SFNVEVVTPALGC--LNLSPAKTIGSMRMASGTKFVPGHRK--CRSLGTKFRSSSLPRNFAEK-- 475
            .|..........|  |:..|....||......||::. |..  |..||..|..:.....|.:.
Mouse   494 DFERLSGNFPFACHGLHPPPRHGSGSFSREELTKYLL-HASAICSKLGLAFLHAFQEVTFRKPTF 557

  Fly   476 CQCCIVMIAPG-IGTISNKRCRCRRIFGKIATHNH 509
            |..|...::.| :..::.:..|||..  .:..|.|
Mouse   558 CHSCSGFVSTGPLWGVTKQGYRCRDC--GLCCHRH 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	62/247 (25%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgrp4	XP_017177648.1	REM	86..168	CDD:383003	5/31 (16%)
		RasGEF	201..436	CDD:214539	64/257 (25%)
		C1	545..599	CDD:237996	9/48 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910