DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and Rapgef5

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001360918.1	Gene:	Rapgef5 / 217944	MGIID:	2444365	Length:	879	Species:	Mus musculus

Alignment Length:	241	Identity:	63/241 - (26%)
Similarity:	108/241 - (44%)	Gaps:	19/241 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQR 234
            ||.::...|:.:|..|...||....::::....||.|:....:|.|....|...|||...|..:|
Mouse   647 LALELMSFDWSLFNSIHEQELIYFTFSRQGNGENTVNLSLLLQRCNEVQLWVATEILLCSQLGKR 711

  Fly   235 AEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDN 299
            .:::..|||:|.......||:|.|||:..:.:||:.||::||..:..|.:..|..|..:.....|
Mouse   712 VQLVKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLN 776

  Fly   300 WANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKGG---LEPEQRRNKMNNI------LRVIS 355
            ....|...:.::.|.||::.|.|.|:.:|     |:|.   |:......|::.|      ||...
Mouse   777 HKAYRDAFKKMKPPKIPFMPLLLKDVTFI-----HEGNKTFLDNLVNFEKLHMIADTVRTLRHCR 836

  Fly   356 NYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEP 401
            ..|..:....::.:..:.|:..:..|:..|.:||     .|..|||
Mouse   837 TNQFGSDVSPKEQQELKSYVNHLYVIDSQQALFE-----LSHRLEP 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	60/238 (25%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rapgef5	NP_001360918.1	DEP_Epac	98..221	CDD:239884
		RasGEFN	367..498	CDD:214571
		RasGEF	639..878	CDD:214539	63/241 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910