DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and Sos2

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_006515698.1	Gene:	Sos2 / 20663	MGIID:	98355	Length:	1333	Species:	Mus musculus

Alignment Length:	497	Identity:	114/497 - (22%)
Similarity:	196/497 - (39%)	Gaps:	95/497 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 IKSTRRK------NSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSAL 163
            |.|.|.|      .||..:........:.|..:.|...::||.....:......:..|.:.|..:
Mouse   717 ISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHPI 781

  Fly   164 RVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNA 228
            .:     |.|:|||:..::.::||.||....|||:||.:|:||::...:...:.:.|..:.|:.|
Mouse   782 EI-----ARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA 841

  Fly   229 EQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDI 293
            |..::|..:::..:::.:...:|||.:.:..|:||:.|.|:|||..|:..|.::.|...|...::
Mouse   842 ENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDDAVEL 906

  Fly   294 FSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAH----PHKG-GLEPEQRRNKMNNILRV 353
              .||::......|:|:..||:|:.|::||:::..:..:    ..|| .|....:|.|:..|...
Mouse   907 --SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGE 969

  Fly   354 ISNYQQSNYKHLQKHEATQKYLTSIRYIEEL-------QNIFEEDQYKRSLNLEPAS----PSGP 407
            |..||  |..:..:.|...:     |:.|.|       :..|.:..:.:||.:||.:    |..|
Mouse   970 IQQYQ--NQPYCLRTEPEMR-----RFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRFP 1027

  Fly   408 SSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRK-----------CRSLGT 461
            ..|:.|.|                 ||.....:.|..|.:..:.||..           .|...|
Mouse  1028 RKSTFSLK-----------------SPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAET 1075

  Fly   462 KFRSS-SLPRNFAEKCQCCIVMIAPGIGTIS-------------NKRCRCRRIFGKI-----ATH 507
            :..|: |.|.:          ...|....:|             |..|....||..:     .|.
Mouse  1076 ELESTVSAPTS----------PNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKTF 1130

  Fly   508 NHSDGHPHHLHLE-LDPSQVQPRHHLLDDSVLEHSDALSQAD 548
            ..|.|..|.|..| |.|..:.||.. .|...|....|:...|
Mouse  1131 FSSCGSLHKLSEEPLIPPPLPPRKK-FDHDALNSKGAVKSDD 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	64/248 (26%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Sos2	XP_006515698.1	Histone	70..169	CDD:333859
		RhoGEF	200..387	CDD:238091
		PH_SOS	438..544	CDD:269963
		RasGEFN	596..740	CDD:214571	6/22 (27%)
		RasGEF	775..1019	CDD:214539	67/257 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810