DRSC/TRiP Functional Genomics Resources

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Protein Alignment RalGPS and Sos1

DIOPT Version :10

Sequence 1:NP_725613.1 Gene:RalGPS / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_033257.2 Gene:Sos1 / 20662 MGIID:98354 Length:1319 Species:Mus musculus


Alignment Length:593 Identity:129/593 - (21%)
Similarity:230/593 - (38%) Gaps:138/593 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 SKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALR 164
            :|.:..|...|.|..|...:|.|||  |...:.|           |.|.|  |:..|.:.|..:.
Mouse   734 TKIIQRKKIARDNGPGHNITFQSSP--PTVEWHI-----------SRPGH--IETFDLLTLHPIE 783

  Fly   165 VPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAE 229
            :     |.|:|||:..::..:||.||....|||:||.:|:||::...:...:.:.|..:.|:..|
Mouse   784 I-----ARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETE 843

  Fly   230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIF 294
            ..::|..:::..|::.:...||||.:.:..::|||.|:.:|||..|:..:..:.:...:...:: 
Mouse   844 NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL- 907

  Fly   295 SDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHP-----HKGGLEPEQRRNKMNNILRVI 354
             .:|::....:.|.|:..||:|:.|::||:::..:..:|     |...|....:|.::..|...|
Mouse   908 -SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGEI 971

  Fly   355 SNYQQSNYKHLQKHEATQKYLTSIRYI-EELQNIFEEDQYKRSLNLEPASPSG----PSSSSCSS 414
            ..||...| .|:.....:::..::..: ..::..|.:..:.:||.:||..|..    |       
Mouse   972 QQYQNQPY-CLRVEPDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRHPKPLPRFP------- 1028

  Fly   415 KESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCC 479
             :.::..:.:|.:...|..|    |:||..:..:..|         .|...|.:|.:..|.....
Mouse  1029 -KKYSYPLKSPGVRPSNPRP----GTMRHPTPLQQEP---------RKISYSRIPESETESTASA 1079

  Fly   480 ------IVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGH------------------------- 513
                  .:...|..||.||... | .:|.  :.|:.|..|                         
Mouse  1080 PNSPRTPLTPPPASGTSSNTDV-C-SVFD--SDHSASPFHSRSASVSSISLSKGTDEVPVPPPVP 1140

  Fly   514 ----PHHLHLELDPSQVQPRHHLLDD---------SVLEHSDALSQADLTSLESAEGIMCDFTGS 565
                |.....|..||::..:|  ||.         :...:|...|.:|.||:            |
Mouse  1141 PRRRPESAPAESSPSKIMSKH--LDSPPAIPPRQPTSKAYSPRYSISDRTSI------------S 1191

  Fly   566 DCDLMSPEAAAAMHGCVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERND--FK 628
            |    .||:...:   ..|:.|    |.|.|.|.....||         ||...|.|:..:  |.
Mouse  1192 D----PPESPPLL---PPREPV----RTPDVFSSSPLHLQ---------PPPLGKKSDHGNAFFP 1236

  Fly   629 REPCKVCP 636
            ..|....|
Mouse  1237 NSPSPFTP 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RalGPSNP_725613.1 RasGEF 169..335 CDD:459872 44/170 (26%)
PH_RalGPS1_2 578..692 CDD:270120 15/61 (25%)
Sos1NP_033257.2 HFD_SOS1_rpt1 18..95 CDD:467039
HFD_SOS1_rpt2 104..177 CDD:467040
RhoGEF 204..389 CDD:214619
PH_SOS 439..545 CDD:269963
RasGEFN 597..741 CDD:214571 1/6 (17%)
RasGEF 776..1015 CDD:238087 56/246 (23%)
PTZ00449 <1017..1305 CDD:185628 56/287 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1101 18/102 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1319 31/158 (20%)
Blue background indicates that the domain is not in the aligned region.

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