DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and Rasgrp1

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_035376.1	Gene:	Rasgrp1 / 19419	MGIID:	1314635	Length:	795	Species:	Mus musculus

Alignment Length:	428	Identity:	91/428 - (21%)
Similarity:	158/428 - (36%)	Gaps:	122/428 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDE-----LSSCAWTKKDKHV 202
            :|.:.::.|.|:..:::...|.  .:.|:..:|.|:|..|.:|...:     ::||.       .
Mouse   184 TQRIKSNTSKKRKVSLLFDHLE--PEELSEHLTYLEFKSFRRISFSDYQNYLVNSCV-------K 239

  Fly   203 NTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSA 267
            ..|.:.......|..|.|....:|:...|:.|||:...||.||:|||:|.|.::|.|:|..:..:
Mouse   240 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHS 304

  Fly   268 SIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANL-RSYLESLRLPCIPYLGLFLTDLIYIDLA 331
            ||.||.:|.:.:..:.......::::.|...|:.|. |:|.|..... ||.||:.|.|||.:..|
Mouse   305 SISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFK-IPILGVHLKDLISLYEA 368

  Fly   332 HPHKGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEE------------- 383
            .|                      :|.:....::||..|...::..:..::|
Mouse   369 MP----------------------DYLEDGKVNVQKLLALYNHINELVQLQEMAPPLDANKDLVH 411

  Fly   384 -----LQNIFEEDQ-YKRSLNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMR 442
                 |...:.||: |:.|...||.:...|.                       |:|:|....:.
Mouse   412 LLTLSLDLYYTEDEIYELSYAREPRNHRAPP-----------------------LTPSKPPVVVD 453

  Fly   443 MASGT------KFVPGHRKCRSLGTKFR------------------SSSLPRNFAEKCQCCIVMI 483
            .|||.      |.:..|.: |.:.:.|:                  ::|.|.:|.       ||.
Mouse   454 WASGVSPKPDPKTISKHVQ-RMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFC-------VMD 510

  Fly   484 APGIGTISNKR-----CRCRRIFGKIATHNHSDGHPHH 516
            ....|.||...     .|...|:.|:..     |.||:
Mouse   511 KDREGLISRDEITAYFMRASSIYSKLGL-----GFPHN 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	61/261 (23%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgrp1	NP_035376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		RasGEFN	54..176	CDD:214571
		Ras exchanger motif region, required for transforming activity	57..110
		RasGEF	201..437	CDD:214539	63/267 (24%)
		EFh	474..521	CDD:238008	9/53 (17%)
		EF-hand_7	478..526	CDD:290234	9/54 (17%)
		C1_1	542..591	CDD:278556	1/2 (50%)
		Suppress the PT region-mediated translocation to plasma membrane	686..694
		PT region, mediates the BCR-dependent translocation to plasma membrane	717..795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810