Protein Alignment RalGPS and Rasgrf2

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_036013814.1
• Gene: Rasgrf2 / 19418
• MGIID: 109137
• Length: 1190
• Species: Mus musculus
• Alignment Length: 563
• Identity: 133/563 - (23%)
• Similarity: 208/563 - (36%)
• Gaps: 170/563 - (30%)

  Fly     2 MRYSEISRDLS--TDNLRY--------------------------SELSRKPTTDYNGYTGQAYA 38
            :||:.:.|.|.  || ||:                          |::.::|.|.....:.:.:.
Mouse   639 IRYASVERLLERLTD-LRFLSIDFLNTFLHTYRIFTTATVVLAKLSDIYKRPFTSIPVRSLELFF 702

  Fly    39 ATQ----------------FKQSSPPPPPSQQQQQPTRVSK------------------------ 63
            ||.                .|.|||||....:...|.|..|
Mouse   703 ATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTNSSSSSS 767

  Fly    64 ----QRSPNTNGSAHTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSP 124
                ..||..:...||.|.|  |....::..:...|.|..|.| ..:..|.:...|.:...:...
Mouse   768 PTTTTHSPAASPPPHTAAVL--ESAPADKAGDSADMSPCRSPT-TPRHLRYRQPGGQVADSAHCS 829

  Fly   125 DSPGCYYTIAASAA----PPSKSQS------------------------LPAHASIKQLD----- 156
            .||...:.||.:||    ||..:..                        :..||...:|:
Mouse   830 VSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKM 894

  Fly   157 -----------------------AVILSAL----------------------------RVPADVL 170
                                   |.||.||                            .:.|..|
Mouse   895 NVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMEL 959

  Fly   171 ANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRA 235
            |.||||||..||..|..:|.....|.|.||:..||.|:..::.||..|.....:|:|......||
Mouse   960 AEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRA 1024

  Fly   236 EIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNW 300
            ..|..::.||.....|:|.:.:..|.||:..::||||.||||.:||:.:...|:|....|.:..:
Mouse  1025 NAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRF 1089

  Fly   301 ANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNILRVISNYQQSNYK 363
            .|||..|::...|.:||||::||||.:|:...|:  :.||....:...:::|:|.|..:||:.|:
Mouse  1090 KNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYR 1154

  Fly   364 HLQKHEATQKYLTSIRYIEELQNIFEEDQ-YKRSLNLEPASPS 405
            ..|:.:.       |:|:.:...:.:||. |:.||.:||..|:
Mouse  1155 IDQQPKV-------IQYLLDKALVIDEDSLYELSLKIEPRLPA 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	62/167 (37%)
		PH_RalGPS1_2	578..692	CDD:270120
Rasgrf2	XP_036013814.1	PH_RasGRF1_2	19..158	CDD:270081
		RhoGEF	247..428	CDD:214619
		PH	480..588	CDD:214574
		RasGEF_N	638..>686	CDD:459873	9/47 (19%)
		REM	<853..925	CDD:470601	7/71 (10%)
		RasGEF	951..1187	CDD:214539	80/242 (33%)