DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and Rasgrf1

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_035375.1	Gene:	Rasgrf1 / 19417	MGIID:	99694	Length:	1262	Species:	Mus musculus

Alignment Length:	338	Identity:	97/338 - (28%)
Similarity:	156/338 - (46%)	Gaps:	63/338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 YKEQQMEPPSMQPQASK-------TLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSK 142
            :.|:.|..|.:..|..|       ||.::.|..::|:
Mouse   971 FLEEVMHDPDLLTQERKAAANIIRTLTLEETTEQHSM---------------------------- 1007

  Fly   143 SQSLPAHASIKQLDAVILSALRV--------PADVLANQITLLDFPVFAQIQPDELSSCAWTKKD 199
                        |:.|||....|        ||..:|.|:||||..||..|..:|.....|.|.:
Mouse  1008 ------------LEEVILMTEGVKTEPFENHPALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAE 1060

  Fly   200 KHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAM 264
            |:..||.|:..||.|||.|.:...||:..|....||..|..::.||.....|:|.:::..|.|::
Mouse  1061 KYERTPYIMKTTKHFNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSI 1125

  Fly   265 QSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYID 329
            ..::|:||.|||..:||:.::..|:|..:.|....:.|||..|.:...||:||||::||||::|:
Mouse  1126 NRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIE 1190

  Fly   330 LAHPH--KGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQ 392
            ...|:  :.||....:...:::|:|.|..:||:.|| :.......:||     ::|...:.||..
Mouse  1191 EGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYK-IDPQPKVIQYL-----LDESFMLDEESL 1249

  Fly   393 YKRSLNLEPASPS 405
            |:.||.:||..|:
Mouse  1250 YESSLLIEPKLPT 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	81/246 (33%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgrf1	NP_035375.1	PH-like	19..155	CDD:302622
		PH	24..130	CDD:278594
		RhoGEF	248..429	CDD:214619
		PH-like	435..586	CDD:302622
		PH	482..587	CDD:278594
		RasGEF_N	638..>687	CDD:279012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..854
		REM	<927..996	CDD:295342	5/24 (21%)
		RasGEF	1023..1259	CDD:214539	81/241 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810