Protein Alignment CG5522 and rgef-1

DIOPT Version :9

• Sequence 1: NP_725613.1
• Gene: CG5522 / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_505469.3
• Gene: rgef-1 / 179344
• WormBaseID: WBGene00009100
• Length: 654
• Species: Caenorhabditis elegans
• Alignment Length: 563
• Identity: 128/563 - (22%)
• Similarity: 212/563 - (37%)
• Gaps: 160/563 - (28%)

  Fly    96 QPQ-ASKTLNIK--------STRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHAS 151
            ||| .::.:.:|        :.|....:..|.||:         :..|.|...|...|:
 Worm    95 QPQVCAQVVRLKTIAEDINENIRNGLDVSALPSFA---------WLRAVSVRNPLAKQT------ 144

  Fly   152 IKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNT-PNIVAFTKRFN 215
                 |..||.::.....::..::.:|:.|.::|...||....   ||.|:.: |.:......||
 Worm   145 -----AFSLSFVQASPSDISTSLSHIDYRVLSRISITELKQYV---KDGHLRSCPMLERSISVFN 201

  Fly   216 HTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLS 280
            :.|.|....|||...||:||||:..|:.|||.|.::||.::|.:::..:..:|:.||.||:|.||
 Worm   202 NLSNWVQCMILNKTTPKERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYAVLS 266

  Fly   281 KKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPC-----IPYLGLFLTDLIYIDLAHPHKGGLEP 340
            ...:....:|:::.|.|.|:...|..|.:    |     ||.:|:.|.||:.|:.:     |...
 Worm   267 NDIKKELTQLTNLLSAQHNFCEYRKALGA----CNKKFRIPIIGVHLKDLVAINCS-----GANF 322

  Fly   341 EQRR----NKMNNILRVISNYQQSNYKHLQKHEA------TQKYLTSIRYIEELQNIFEEDQYKR 395
            |:.:    :|:..:.:::||:...|.|.....|.      |.|....|||       .::|.|:.
 Worm   323 EKTKCISSDKLVKLSKLLSNFLVFNQKGHNLPEMNMDLINTLKVSLDIRY-------NDDDIYEL 380

  Fly   396 SLNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLG 460
            ||..||              ::|           :|..|::.:.....|||....|.:    :..
 Worm   381 SLRREP--------------KTF-----------MNFEPSRGLVFAEWASGVTVAPDN----ATV 416

  Fly   461 TKFRSSSLPRNF------------AEKCQCCIVMIA---PGI-----------GTISNKRCRCRR 499
            :|..|:.:...|            .|:.|    :||   |.|           |.||....   :
 Worm   417 SKHISAMVDAVFKHYDHDRDGFISQEEFQ----LIAGNFPFIDAFVNIDVDMDGQISKDEL---K 474

  Fly   500 IFGKIATHNHSD---GHPHHLHLELDPSQVQPRHHLLDDSVLEHSDALSQADLTSLESAEGIMCD 561
            .:...|..|..|   |..|:.|          ....|..:...|.:.|....|     .:|..|
 Worm   475 TYFMAANKNTKDLRRGFKHNFH----------ETTFLTPTTCNHCNKLLWGIL-----RQGFKC- 523

  Fly   562 FTGSDCDLMSPEAAAAMHGCVRRKTVQKEGRKPA-----VASW 599
               .||.|       |:|.|.:...|.:..||.:     .|.|
 Worm   524 ---KDCGL-------AVHSCCKSNAVAECRRKSSSNLTRAAEW 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	69/252 (27%)
		PH_RalGPS1_2	578..692	CDD:270120	7/27 (26%)
		PH	578..685	CDD:278594	7/27 (26%)
rgef-1	NP_505469.3	RasGEF	150..388	CDD:214539	71/270 (26%)
		EFh	423..473	CDD:238008	10/53 (19%)
		EF-hand_7	427..477	CDD:290234	10/56 (18%)
		C1	493..542	CDD:237996	15/74 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910