Protein Alignment RalGPS and sos-1

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_504235.2
• Gene: sos-1 / 178846
• WormBaseID: WBGene00004947
• Length: 1493
• Species: Caenorhabditis elegans
• Alignment Length: 722
• Identity: 151/722 - (20%)
• Similarity: 245/722 - (33%)
• Gaps: 190/722 - (26%)

  Fly    50 PPSQQQQQPTRVSKQRSPNTNG------SAHTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKST 108
            ||...||          ||.||      ..|..:..    .:.:.|..||..|
 Worm   827 PPGIMQQ----------PNENGDKGAADEGHVNSAF----VFGDDQQHPPQHQ------------ 865

  Fly   109 RRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALRVPADVLANQ 173
                                 .||   :.:|...:|.|...|....:|...|..|. |.:: ..|
 Worm   866 ---------------------VYT---NESPKETNQVLWHTAQKGDVDHYDLLTLH-PIEI-GRQ 904

  Fly   174 ITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEII 238
            :|||...::..|||.||...||||.:|...:|.::..|......::|..:.|:..|..::|..:.
 Worm   905 LTLLHSDLYRAIQPIELVEAAWTKAEKWRKSPQLLRLTDHSTLLTYWVSRSIVETESLEERMAMF 969

  Fly   239 THFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANL 303
            ...::|.....||:|...|.|..||:.|:.|:||...|..|..:.:..|||.:.:.  :..|..:
 Worm   970 NRVLEVMSVFEELHNFTGLVAFYSALNSSCIFRLKWCWDGLDNEKKKCFDRFNTLC--ERRWQEM 1032

  Fly   304 RSYLESLRLPCIPYLGLFLTDLIYIDLAH--------PH-KGGLEPEQRRN-------------- 345
            :..|.|:..||||:.|.:|:::.:::..:        || ..|.:.:|:.:
 Worm  1033 QKRLSSINPPCIPFFGHYLSNIYFLEQGNSTFVNKSPPHGAAGAQKQQKDDLKASDPENSNKQFK 1097

  Fly   346 ---------KMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQN--IFEEDQYKRSLNL 399
                     |::|::|.|..:|...|. |......:::..||....:.::  ..||..|.:||.:
 Worm  1098 QLVSFLKLRKISNVIREIQIFQDQRYS-LTLEPTIRQFFESINPKNDFKSNEDLEEYLYNKSLEI 1161

  Fly   400 EPASPSGPSSSSCSSKESFNVEVV-TPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKF 463
            :   |.|..:.:...|...|...: :|     .:.|.|       |:|..:...|    .:|...
 Worm  1162 Q---PKGLDTPTAELKPKHNASTLRSP-----GVKPPK-------AAGNHYSANH----PIGLHL 1207

  Fly   464 RSS---SLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDG------------- 512
            .|.   |.|.  |...|...|...| :.....||.         .:||..|.
 Worm  1208 HSQNSHSAPH--AMSSQSSTVPNTP-LSAHETKRS---------LSHNQDDAPLQQFVDIRFERK 1260

  Fly   513 --HPHHLHLELDPSQVQPRHHLLDDSVLEHSDALSQADLTSLESAEGIMCDFTGSD--CDLMSPE 573
              ||....|:  |..:.||....:.|........:||.:.....:.|:|...|...  ....:|.
 Worm  1261 GTHPKIPVLQ--PPPLLPRSSRANQSNSVSLPPTTQAPMPPAPKSSGMMSTATSPTTLTTTTTPS 1323

  Fly   574 AAAA----MHGCVRRKTVQKE---GRKPAVASWQRYWLQIWANSLVY----FPPKSFKGSERNDF 627
            :|..    :|  .||.|.|..   .:.|...|........:...:||    .||...:.|..:|.
 Worm  1324 SAGGPPPKLH--PRRMTQQPMSPLAKSPLTPSRDNSSPSAFQFPVVYEASTAPPLPPRPSTSSDV 1386

  Fly   628 KREPCKVCPLDGWYAHVSDNTKHKNTFELCHRTLGTVY-RFRTDSPQMTHLWSNAICKLATMRVP 691
            ...|       ......|..||..      ...|..:: |..:.||              |:|:.
 Worm  1387 SSSP-------STSGSTSSATKEN------QEQLRVIFDREESHSP--------------TVRLS 1424

  Fly   692 KPLPTNL 698
            .|||..|
 Worm  1425 VPLPPAL 1431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	48/174 (28%)
		PH_RalGPS1_2	578..692	CDD:270120	23/121 (19%)
sos-1	NP_504235.2	HFD_SF	<153..204	CDD:480273
		RhoGEF	248..447	CDD:470622
		PH-like	493..604	CDD:473070
		RasGEF_N	659..794	CDD:459873
		RasGEF	900..1067	CDD:459872	46/169 (27%)
		PHA03247	<1277..1379	CDD:223021	20/103 (19%)