DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and Rasgrp4

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_038939950.1	Gene:	Rasgrp4 / 170668	RGDID:	620476	Length:	726	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	104/489 - (21%)
Similarity:	180/489 - (36%)	Gaps:	97/489 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSL 146
            |..::|.|:|  ::..:...|:..:....:.|:|..::. .||..||          ||    .|
  Rat   182 EVVHQEPQLE--AIINRFWTTVAQEGNMAQRSLGDASNL-LSPGGPG----------PP----PL 229

  Fly   147 PAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFT 211
            .:...:.:...|.|....:..:.||..:|.|:|..|..|.|.:|.  .:..:......|.:....
  Rat   230 MSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLR--GYVLQGSVRGCPALEGSV 292

  Fly   212 KRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTW 276
            ...|..|.|....:|:...|.|||:::..||:||::|.::.|.::|.|:...:..::|.||..:.
  Rat   293 GLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSH 357

  Fly   277 ACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEPE 341
            ..||.....|...|:::.|..:|:|..|....|.....:|.||:.|.||:.:..|||.:   .|:
  Rat   358 VHLSPDSTKALLELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDR---LPD 419

  Fly   342 QRRN--KMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIF---------EEDQYKR 395
            .|.:  |:|::           |..||:..|.|:........|:|.::.         |::.|:.
  Rat   420 GRLHLPKLNSL-----------YLRLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYEL 473

  Fly   396 SLNLEPASPSG-------------------------------------------PSSSSCSSKES 417
            |...||..|..                                           |......|.|.
  Rat   474 SYAREPRCPKSLPLSPFKAPVVVEWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLED 538

  Fly   418 FNVEVVTPALGC--LNLSPAKTIGSMRMASGTKFVPGHRK--CRSLGTKFRSSSLPRNFAEK--C 476
            |..........|  |:..|....||......||::. |..  |..||..|..:.....|.:.  |
  Rat   539 FEKLSANFPFACHGLHPPPRHGSGSFSREELTKYLL-HASAICSKLGLAFLHAFQEVTFRKPTFC 602

  Fly   477 QCCIVMIAPG-IGTISNKRCRCRRIFGKIATHNH 509
            ..|...::.| :..::.:..||:..  .:..|.|
  Rat   603 HSCNGFVSTGPLWGVTKRGYRCQDC--GLCCHRH 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	61/247 (25%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgrp4	XP_038939950.1	REM	105..220	CDD:100121	7/40 (18%)
		RasGEF	245..480	CDD:214539	62/250 (25%)
		C1	586..647	CDD:412127	9/51 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810