Protein Alignment RalGPS and RalGPS

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_314338.5
• Gene: RalGPS / 1275114
• VectorBaseID: AGAMI1_007585
• Length: 674
• Species: Anopheles gambiae
• Alignment Length: 758
• Identity: 301/758 - (39%)
• Similarity: 403/758 - (53%)
• Gaps: 140/758 - (18%)

  Fly     1 MMRYSEISRDLSTDNLRYSELSRKPTT------------DYNGYTGQAYAATQFKQSSPPPPPSQ 53
            |||||||.|||:..:...|::.|...|            .|:|.....|.    :.||.....||
Mosquito     1 MMRYSEIPRDLADRHTCKSKVGRDTKTGRSLSSTGGHNESYDGDGDDGYE----QLSSSDGNVSQ 61

  Fly    54 QQQQPTRVSKQRSPNTNGSAHTMAC---LRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIG 115
            ..|...:.       .:||..|...   .|:.:.::::|.:        .|.|..|:|  ..||.
Mosquito    62 PNQHAEKA-------LDGSIDTPLIEDGKRKPERHRDRQPD--------DKHLCHKAT--AGSIE 109

  Fly   116 CLNSFSSSPDSPGCYYTIAASAAP----PSKSQSLPAHASIKQLDAVILSALRVPADVLANQITL 176
            .||.        ||..|  :|..|    ..||.|||.:.:|..:.:::.|..:|....||.||||
Mosquito   110 SLND--------GCSAT--SSFRPWHSYSKKSYSLPPNTTISDVGSIVFSCQQVSPAELAAQITL 164

  Fly   177 LDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHF 241
            ||||:|..|||:||:||.||||:||...||:||||||||||:|||||||||...||.|||||:||
Mosquito   165 LDFPIFNAIQPEELTSCGWTKKNKHTLAPNVVAFTKRFNHTTFWTVQEILNGVSPKDRAEIISHF 229

  Fly   242 IKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSY 306
            ||||||||::||||||||:|||::|||::||.::|..:|:||:...||||.:|.:.|||::||..
Mosquito   230 IKVAKKLHDINNLHSLFAVISALKSASVHRLKESWLLVSRKDQQQLDRLSHLFDESDNWSSLRKC 294

  Fly   307 LESLRLPCIPYLGLFLTDLIYIDLAHPHKGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEAT 371
            |...:||.|||||:||||:|||||.||:|.|.|...|..||||:|||:|:||.|||..:.....|
Mosquito   295 LNQFKLPGIPYLGIFLTDIIYIDLMHPNKSGEESYARETKMNNVLRVLSSYQSSNYTFISPVPPT 359

  Fly   372 QKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSS---------SCSSKESF--NVEVVTP 425
            .:||.|.|||:||||||||||||:||||||.:.:...||         .....:|.  ||:....
Mosquito   360 LRYLQSRRYIDELQNIFEEDQYKKSLNLEPTAGASTMSSGGTVRLLKPKIEQSDSIGRNVKTTIA 424

  Fly   426 ALGCLNLSP-----AKTIGSMRMASGTKFVPGHRKCRSLGTKF---RSSSLPRNFAEKCQCCIVM 482
            ...|.: ||     |.......::|..:|:||||||.||||..   |||....:.:.........
Mosquito   425 LAECKD-SPDSTTCAPNTSQTIVSSARQFIPGHRKCYSLGTNIFYPRSSEQSSSSSSASSSRHTK 488

  Fly   483 IAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLE-------- 539
            :|.|:    ||                                   ..||||||.:|
Mosquito   489 VADGL----NK-----------------------------------MRHLLDDSYVESKRANSIA 514

  Fly   540 -------HSDALSQADLTSLESAEGIMCDFTGSDCDLMSP-EAAAAMHGCVRRKTVQKEGRKPAV 596
                   ||........|:|:..|             :.| .:...:.|.::||||.|.||||.|
Mosquito   515 ATGSGGSHSSDQESEHPTALQLVE-------------LEPITSGNLVEGYLKRKTVLKYGRKPTV 566

  Fly   597 ASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVSDNTKHKNTFELCHRTL 661
            |||||||:.||:|:::|||||:|||:||::||:||.|:.||:||.|..||.......|:|.:...
Mosquito   567 ASWQRYWVLIWSNTMIYFPPKTFKGNERSNFKKEPSKIFPLEGWTAEESDLPLQDEFFQLVNYNH 631

  Fly   662 GTVYRFRTDSPQMTHLWSNAICKLATMRVPKPL--PTNLMSFE 702
            |..|||::.|....:.|..|:.::.|.:..:||  ..||:|||
Mosquito   632 GHAYRFKSGSNASANRWLAALKQVTTPKPAEPLSISLNLISFE 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	111/165 (67%)
		PH_RalGPS1_2	578..692	CDD:270120	53/113 (47%)
RalGPS	XP_314338.5	None