DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and RASGRP4

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_733749.1	Gene:	RASGRP4 / 115727	HGNCID:	18958	Length:	673	Species:	Homo sapiens

Alignment Length:	314	Identity:	82/314 - (26%)
Similarity:	130/314 - (41%)	Gaps:	51/314 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 SPDSPGCYYTIAASAAPPSKSQSLP-AHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQ 186
            ||..||          ||     || :...:.:...|.|....:....||..:|.|:|..|..|.
Human   172 SPGGPG----------PP-----LPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221

  Fly   187 PDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHEL 251
            |.:|.|  :..:......|.:.......|..|.|....:|:...|.|||:::..||.||::||:|
Human   222 PQDLRS--YVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQL 284

  Fly   252 NNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIP 316
            .|.::|.|:...:..::|.||..:.|.||.....|...|:::.:..:|:|..|..........:|
Human   285 QNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLP 349

  Fly   317 YLGLFLTDLIYIDLAHPHKGGLEPEQRRN--KMNNILRVISNYQQSNYKHLQKHEATQKYLTSIR 379
            .||:.|.||:.:..|.|.:   .|:.|.:  |:||:           |..||:..|.|.......
Human   350 VLGVHLKDLVSLHEAQPDR---LPDGRLHLPKLNNL-----------YLRLQELVALQGQHPPCS 400

  Fly   380 YIEELQNIF---------EEDQYKRSLNLEPASP-SGPSSSSCSSKESFNVEVV 423
            ..|:|.::.         |::.|:.|...||..| |.|.|       .||..:|
Human   401 ANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPS-------PFNAPLV 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	63/247 (26%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
RASGRP4	NP_733749.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		REM	57..164	CDD:100121
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..187		8/29 (28%)
		RasGEF	197..432	CDD:214539	64/250 (26%)
		C1	541..590	CDD:197519
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..621
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810