Protein Alignment RalGPS and RASGRP2

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_011543020.1
• Gene: RASGRP2 / 10235
• HGNCID: 9879
• Length: 715
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 139/640 - (21%)
• Similarity: 231/640 - (36%)
• Gaps: 207/640 - (32%)

  Fly    24 KPTTDYNGYTGQAYAATQFKQS-----SPPPPPSQQQQQP---TRVSKQRSPNTNGSAHTMACLR 80
            :|.....|:|...:..:....|     :.|.|..:..|.|   ||.::.||.:...|
Human    97 RPRVCILGWTSWGFGPSPVGGSRSAAWAQPTPRRRPWQAPWTWTRAARWRSCSAGAS-------- 153

  Fly    81 QEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCY---YTIAASAAP--- 139
                       .||:   |:|.|:|....||::       |:|.....|:   |.|:|..|.
Human   154 -----------KPSL---AAKLLHIYQQSRKDN-------SNSLQVKTCHLVRYWISAFPAEFDL 197

  Fly   140 -PSKSQSLP------------AHASIKQLDAVILSALRVPADVLANQITLLDFPV---------- 181
             |..::.:.            .|:|:..:|:       ||......|:|..: ||
Human   198 NPELAEQIKELKALLDQEGNRRHSSLIDIDS-------VPTYKWKRQVTQRN-PVGQKKRKMSLL 254

  Fly   182 FAQIQPDEL----------SSCAWTKKDKH--------VNTPNIVAFTKRFNHTSFWTVQEILNA 228
            |..::|.||          |.|....:|.|        |:.|.:..|...||..|.|....||:.
Human   255 FDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSK 319

  Fly   229 EQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDI 293
            ....|||.:||||:.||:||.:|.|.::|.|::..:..:||.||.:|.:.:|.:....::.|:::
Human   320 PTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTEL 384

  Fly   294 FSDQDNWANLRSYLESLRLPCI----PYLGLFLTDLIYIDLAHPHKGGLEPEQRR---NKMNNIL 351
            .:...|:.|.|..|.:    |:    |.||:.|.||:.:.||.|  ..|:|.:.|   .||..:.
Human   385 VTATGNYGNYRRRLAA----CVGFRFPILGVHLKDLVALQLALP--DWLDPARTRLNGAKMKQLF 443

  Fly   352 RVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSS-SSCS-- 413
            .::.  :.:....|:........|.|:..:...|...|::.|:.||..||.|.|.|:| :||:
Human   444 SILE--ELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPP 506

  Fly   414 ---------------------------------------------SKESFNV------------E 421
                                                         |:|.|.:            :
Human   507 PRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGD 571

  Fly   422 VVTPALGCLN--------LSPAKTIGSMRMASGTKFVPGH-------RKCRSLGTKFRSSSLPRN 471
            :.....||::        |..:..:|. ||.....|...:       |.|::|........|
Human   572 LDQNQDGCISREEMVSYFLRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGL--- 632

  Fly   472 FAEKCQCCIVMIAPGIGTISNKRCR------CRRIFGKIATH----NHSDGHPHH 516
               ||:.|        |...:|:|:      |||....::..    :.|..|.||
Human   633 ---KCRAC--------GVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPMHSHH 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	57/197 (29%)
		PH_RalGPS1_2	578..692	CDD:270120
RASGRP2	XP_011543020.1	RasGEF	255..492	CDD:214539	67/244 (27%)
		FRQ1	<512..589	CDD:444056	5/76 (7%)
		C1	601..656	CDD:412127	13/68 (19%)