DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rapgef3

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_005162410.1	Gene:	rapgef3 / 101886094	ZFINID:	ZDB-GENE-090312-38	Length:	885	Species:	Danio rerio

Alignment Length:	329	Identity:	77/329 - (23%)
Similarity:	132/329 - (40%)	Gaps:	63/329 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PSKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAW-TKKDKHVN 203
            |.|.|..|..:::..|:       ::.:..:|:|.|..|:.:|..:...||....: .:|.....
Zfish   605 PDKEQLGPEKSTMDTLE-------QICSKDMASQHTSYDWELFMAMHEVELVYYVFGREKFPGST 662

  Fly   204 TPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSAS 268
            |.|:..|.:|||...:|.|.|:...|...:||.::..|||:|..|.|..||:|.||::..:.:::
Zfish   663 TANLERFVRRFNEVQYWVVTELCLCEDLGKRAILLKKFIKMAVVLKEQKNLNSFFAVMFGLSNSA 727

  Fly   269 IYRLTKTWACLSKKDRN---AFDRLSDIFSDQDNWANLRSY---LESLRLPCIPYLGLFLTDLIY 327
            :.||.|||..|..|.:.   |::||      .|...|.|:|   :..|..|.||::.|.|.|:.:
Zfish   728 VQRLNKTWERLPNKTKRIYCAYERL------MDPSRNHRAYRLTIAKLSPPYIPFMPLLLKDMTF 786

  Fly   328 IDLAHPHKGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQ 392
            |                                       ||..:.|...:...|:::.|....:
Zfish   787 I---------------------------------------HEGNKNYTDKLVNFEKMRMIARTVK 812

  Fly   393 YKRSLNLEPASPSGPSSSSCSSK--ESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRK 455
            ..|....:|..||.|........  ::..:.:.|.:...|||..|.:|  .:.....|.:...:|
Zfish   813 TVRDCRSQPYVPSSPQKGLTERMFLDAQAIRISTYSDQSLNLRSATSI--RQYIQNLKVIDNQKK 875

  Fly   456 CRSL 459
            ...|
Zfish   876 LTQL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	59/243 (24%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rapgef3	XP_005162410.1	DEP_Epac	71..198	CDD:239884
		CAP_ED	222..331	CDD:237999
		Crp	241..>321	CDD:223736
		RasGEFN	353..485	CDD:214571
		RasGEF	620..884	CDD:214539	73/314 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910