DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and RASGRP1

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_005730.2	Gene:	RASGRP1 / 10125	HGNCID:	9878	Length:	797	Species:	Homo sapiens

Alignment Length:	422	Identity:	91/422 - (21%)
Similarity:	163/422 - (38%)	Gaps:	110/422 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDE-----LSSCAWTKKDKHV 202
            :|.:.::.|.|:..:::...|.  .:.|:..:|.|:|..|.:|...:     ::||.       .
Human   184 TQRIKSNTSKKRKVSLLFDHLE--PEELSEHLTYLEFKSFRRISFSDYQNYLVNSCV-------K 239

  Fly   203 NTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSA 267
            ..|.:.......|..|.|....:|:...|:.|||:...||:||:|||:|.|.::|.|:|..:..:
Human   240 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHS 304

  Fly   268 SIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANL-RSYLESLRLPC----IPYLGLFLTDLIY 327
            ||.||.:|.:.:..:.......::::.|...|:.|. |:|.|     |    ||.||:.|.|||.
Human   305 SISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGE-----CTDFKIPILGVHLKDLIS 364

  Fly   328 IDLAHPHKGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIF---- 388
            :..|.|.    ..|..:..::.:|.:        |.|:.:....|:....:...::|.::.
Human   365 LYEAMPD----YLEDGKVNVHKLLAL--------YNHISELVQLQEVAPPLEANKDLVHLLTLSL 417

  Fly   389 -----EEDQYKRSLNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGT- 447
                 |::.|:.|...||.:...|.                       |:|:|....:..|||.
Human   418 DLYYTEDEIYELSYAREPRNHRAPP-----------------------LTPSKPPVVVDWASGVS 459

  Fly   448 -----KFVPGHRKCRSLGTKFR------------------SSSLPRNFAEKCQCCIVMIAPGIGT 489
                 |.:..|.: |.:.:.|:                  ::|.|.:|.       ||.....|.
Human   460 PKPDPKTISKHVQ-RMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFC-------VMDKDREGL 516

  Fly   490 ISNKR-----CRCRRIFGKIATHNHSDGHPHH 516
            ||...     .|...|:.|:..     |.||:
Human   517 ISRDEITAYFMRASSIYSKLGL-----GFPHN 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	61/255 (24%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
RASGRP1	NP_005730.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		RasGEFN	54..175	CDD:214571
		Ras exchanger motif region, required for transforming activity. /evidence=ECO:0000250	57..110
		RasGEF	201..437	CDD:214539	63/261 (24%)
		EF-hand_7	478..527	CDD:372618	9/55 (16%)
		C1_1	542..591	CDD:365894	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..694
		Suppress the PT region-mediated translocation to plasma membrane. /evidence=ECO:0000250	686..694
		PT region, mediates the BCR-dependent translocation to plasma membrane. /evidence=ECO:0000250	718..797
		bZIP	<734..780	CDD:389750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810