Protein Alignment RalGPS and ralgps1

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_031746936.1
• Gene: ralgps1 / 100495235
• XenbaseID: XB-GENE-996181
• Length: 622
• Species: Xenopus tropicalis
• Alignment Length: 684
• Identity: 255/684 - (37%)
• Similarity: 340/684 - (49%)
• Gaps: 175/684 - (25%)

  Fly   121 SSSPDSP--------GCYYTIAASAAPP---SKSQSLPAHAS---IKQLDAVILSALRVPADVLA 171
            :.||..|        |...::..:||.|   |.|.|:...:|   .|..|||:...|:|..:..|
 Frog    12 AKSPSIPWGSMYKRNGLMASVTVTAATPEGSSSSDSMDGQSSDYANKSYDAVVFDVLKVTPEEFA 76

  Fly   172 NQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAE 236
            :||||:|.|||.:|.|:||:||.|.||:||:..||:||||:|||..|||.|:|||.|:..|.|||
 Frog    77 SQITLMDVPVFKEILPEELASCGWNKKEKHILAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAE 141

  Fly   237 IITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWA 301
            |::||:|:||||.||||:|||.|::||:|||.|:|||||||.|::||:..|::|..:.|.:||..
 Frog   142 ILSHFVKIAKKLLELNNIHSLMAVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLLSKEDNCK 206

  Fly   302 NLRSYLESLRL-PCIPYLGLFLTDLIYIDLAHPHKGG-LEPEQRRNKMNNILRVISNYQQS-NYK 363
            .:|.::.||:: ||||||||:|.|:||||.|:|..|. :|.|||.|:||||||:|::.|.| .|.
 Frog   207 RMREHIRSLKMVPCIPYLGLYLLDIIYIDSAYPASGSIMENEQRTNQMNNILRIIADLQVSCIYD 271

  Fly   364 HLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSSSCSSKESFNVEVVTPALG 428
            ||......||||.|:|||||||...|:|.||.||.:||.:   .|....||||..
 Frog   272 HLVTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGN---SSPRLVSSKEDL---------- 323

  Fly   429 CLNLSPAKTIGSMRM--------AS-----GTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCI 480
               ..|::...:||.        ||     .|..|..|||..|||
 Frog   324 ---AGPSEMTATMRFHRRPTCPDASVATNLPTPPVSRHRKSHSLG-------------------- 365

  Fly   481 VMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLEHSDAL- 544
                      :|..|:...:..|.||.               ||:.|  .|||||||||....:
 Frog   366 ----------NNVMCQFSVVESKSATF---------------PSEKQ--RHLLDDSVLESQSPVR 403

  Fly   545 --SQA-------DLTSLESAE-------------------------------------------- 556
              ||.       .|.|.||:|
 Frog   404 NQSQTPVFTNGISLGSSESSEFSEEVSAGLDRGRLYATLGPNWRVPVRNSPRSRSCVYSSTRSER 468

  Fly   557 ---------------GIMCDFTGSDCDLMSPEAAAAMHGCVRRKTVQKEGRKPAVASWQRYWLQI 606
                           |....|.||.      .:|.||.|.:||||:||||:||.:|||.|||:.:
 Frog   469 ASAWIHTGMATVRPTGAYSSFVGSS------SSAIAMEGPLRRKTLQKEGKKPTLASWTRYWVTL 527

  Fly   607 WANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVSDNTKHKNTFELCHRTLGTVYRFRTDS 671
            ..::|:||.|||.:|:||..:|..|.|...:.||...:.|:.:|.|.|:|.:...|.||:|:|.|
 Frog   528 SGSTLLYFGPKSLRGNERKHYKSTPSKKVSILGWMVVLPDDPEHPNIFQLNNPDKGNVYKFQTSS 592

  Fly   672 PQMTHLWSNAI---CKLATMRVPKPLPTNLMSFE 702
            .....||...:   ||    ....|:|.||||||
 Frog   593 RFHAILWHKHLDDACK----STRPPVPANLMSFE 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	97/166 (58%)
		PH_RalGPS1_2	578..692	CDD:270120	47/116 (41%)
ralgps1	XP_031746936.1	RasGEF	67..311	CDD:214539	137/243 (56%)
		PH_RalGPS1_2	499..613	CDD:270120	47/117 (40%)