DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and zbtb22

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_002938727.2	Gene:	zbtb22 / 100488727	XenbaseID:	XB-GENE-6458515	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	226	Identity:	42/226 - (18%)
Similarity:	76/226 - (33%)	Gaps:	71/226 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 EPEQRRNKMNNILRVISNYQ------QSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSL 397
            ||||...:.:  :...|:|:      |.::.:::|....|..|.:....||..:..|||:.:..|
Frog   197 EPEQGGGEAS--VASCSSYRRPSIVPQRHWVYVKKERPHQGLLLTCEGEEEEDDELEEDEEEEQL 259

  Fly   398 NLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTK 462
                         |.|...:.|             :|.:.:.....:.|..:..|     :.|:.
Frog   260 -------------SISDVRTLN-------------APEEQVNFCEPSDGMPYEEG-----AGGSG 293

  Fly   463 FRSSS--LPRNFAEKCQCCIVMIAP---------GIGTISNKR------CRCRRIFGKIATHNHS 510
            :....  ||.:.    |...:::.|         |.||.....      |.|    ||..:|...
Frog   294 YPQGPPLLPLDM----QGNQLLVLPSGHGAAGQGGSGTSPGGEGGKIFLCHC----GKAFSHKSM 350

  Fly   511 DGHPHHLHLELDP-------SQVQPRHHLLD 534
            .....::||.|.|       .:.:.:|||.:
Frog   351 RDRHVNMHLNLRPFDCPVCGKKFKMKHHLTE 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	16/66 (24%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
zbtb22	XP_002938727.2	BTB_POZ_ZBTB22_BING1	12..123	CDD:349519
		C2H2 Zn finger	339..358	CDD:275368	5/22 (23%)
		zf-H2C2_2	352..374	CDD:372612	4/21 (19%)
		zf-C2H2	364..386	CDD:333835	3/18 (17%)
		C2H2 Zn finger	366..386	CDD:275368	3/16 (19%)
		zf-H2C2_2	378..401	CDD:372612	2/4 (50%)
		C2H2 Zn finger	394..418	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910