Protein Alignment RalGPS and rgl3

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_012808636.1
• Gene: rgl3 / 100485337
• XenbaseID: XB-GENE-493046
• Length: 712
• Species: Xenopus tropicalis
• Alignment Length: 567
• Identity: 136/567 - (23%)
• Similarity: 217/567 - (38%)
• Gaps: 139/567 - (24%)

  Fly    80 RQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCL--NSFSSSP----DSPGCY-----YTI 133
            |.|:|.:|:.:.|.|..|.......:        :.||  :.....|    |:|.|.     |..
 Frog   140 RLERTSEEEHVTPGSPVPDTPSVQRV--------VRCLLQSWLEKHPQDFRDAPDCLQLISNYLS 196

  Fly   134 AASAAPPSK----SQSL---------PAHASIK--------QLDAVILSALRVPADVLANQITLL 177
            .....|||.    .|||         |..:.:.        :.....:..|..|...:|.|:||:
 Frog   197 CDKREPPSPLLRLLQSLQEEMEESPTPMGSKVNLQPVEGDTETPGPTIDLLSFPPQDVAEQLTLI 261

  Fly   178 DFPVFAQIQPDELSSCAWTKKDKHVN---TPNIVAFTKRFNHTSFWTVQEILNAEQ--PKQRAEI 237
            |..:|.::|........|:::||..|   .|::.|...:||..:...:..:|:..|  |:|||::
 Frog   262 DVDLFQKLQSCHCLGSIWSQRDKKENRNVAPSVRATVAQFNAVTACVIASVLSDVQLKPQQRAKV 326

  Fly   238 ITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWAN 302
            :..:|.:|:....|.|..||.||:||:||..:|||.:|||.:|:.:.|.|.:|||||||::|...
 Frog   327 LEKWICIAQHCRFLRNFSSLRAILSALQSNPLYRLKRTWAAVSRDNLNIFHKLSDIFSDENNHGM 391

  Fly   303 LRSYLESLRLP-----------------------------CIPYLGLFLTDLIYIDLAHPH--KG 336
            .|..|....:|                             .:||||.||||||.:|.|.|.  :|
 Frog   392 SREILTKEEIPLRRTNSARNEPRPLQRSASQVRSTRVLQGTVPYLGTFLTDLIMLDTALPDCTEG 456

  Fly   337 GLEPEQRRNKMNNILRVISNYQQS--NYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNL 399
            ||...::|.|...:|..|...|.:  :|....|.|..:.:.:.       :.:.|:..|:.|..:
 Frog   457 GLINFEKRRKEYEVLAKIQKLQLTCRHYVLTAKPEILRAFYSQ-------RQLTEDQSYRISRTI 514

  Fly   400 EPASPSGPSSSSCSSKES-------FNVEVVTPALGCLNLSPAKTIGSMRMASG--TKFVPGHRK 455
            ||.:.|.|:|.....|.:       ...||..|.|....:||:.:..|.....|  :...|
 Frog   515 EPPADSCPNSPRIRRKLTKRFSSLLLGSEVFGPKLNGDRVSPSGSCNSCETDDGLISALCP---- 575

  Fly   456 CRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHHLHLE 520
                    ..||..:|..|          ||...               .|..|.|.........
 Frog   576 --------NESSTQKNMQE----------PGTPP---------------TTPRHDDQFRFAPRSP 607

  Fly   521 LDPSQVQPRHH--LLDDSVLE------HSDALSQADLTSLESAEGIM 559
            :.||..||.::  :.|..::.      |.:......|||.:.:..::
 Frog   608 VSPSSTQPLYNQQIADLCIIRVSMENTHGNMYKSILLTSQDKSRAVI 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	66/201 (33%)
		PH_RalGPS1_2	578..692	CDD:270120
rgl3	XP_012808636.1	RasGEF_N	91..191	CDD:459873	13/58 (22%)
		RasGEF	246..517	CDD:214539	83/277 (30%)
		RA_RalGDS_like	623..708	CDD:340449	5/32 (16%)