DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and rgl3

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_012808636.1	Gene:	rgl3 / 100485337	XenbaseID:	XB-GENE-493046	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	567	Identity:	136/567 - (23%)
Similarity:	217/567 - (38%)	Gaps:	139/567 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCL--NSFSSSP----DSPGCY-----YTI 133
            |.|:|.:|:.:.|.|..|.......:        :.||  :.....|    |:|.|.     |..
Frog   140 RLERTSEEEHVTPGSPVPDTPSVQRV--------VRCLLQSWLEKHPQDFRDAPDCLQLISNYLS 196

  Fly   134 AASAAPPSK----SQSL---------PAHASIK--------QLDAVILSALRVPADVLANQITLL 177
            .....|||.    .|||         |..:.:.        :.....:..|..|...:|.|:||:
Frog   197 CDKREPPSPLLRLLQSLQEEMEESPTPMGSKVNLQPVEGDTETPGPTIDLLSFPPQDVAEQLTLI 261

  Fly   178 DFPVFAQIQPDELSSCAWTKKDKHVN---TPNIVAFTKRFNHTSFWTVQEILNAEQ--PKQRAEI 237
            |..:|.::|........|:::||..|   .|::.|...:||..:...:..:|:..|  |:|||::
Frog   262 DVDLFQKLQSCHCLGSIWSQRDKKENRNVAPSVRATVAQFNAVTACVIASVLSDVQLKPQQRAKV 326

  Fly   238 ITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWAN 302
            :..:|.:|:....|.|..||.||:||:||..:|||.:|||.:|:.:.|.|.:|||||||::|...
Frog   327 LEKWICIAQHCRFLRNFSSLRAILSALQSNPLYRLKRTWAAVSRDNLNIFHKLSDIFSDENNHGM 391

  Fly   303 LRSYLESLRLP-----------------------------CIPYLGLFLTDLIYIDLAHPH--KG 336
            .|..|....:|                             .:||||.||||||.:|.|.|.  :|
Frog   392 SREILTKEEIPLRRTNSARNEPRPLQRSASQVRSTRVLQGTVPYLGTFLTDLIMLDTALPDCTEG 456

  Fly   337 GLEPEQRRNKMNNILRVISNYQQS--NYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNL 399
            ||...::|.|...:|..|...|.:  :|....|.|..:.:.:.       :.:.|:..|:.|..:
Frog   457 GLINFEKRRKEYEVLAKIQKLQLTCRHYVLTAKPEILRAFYSQ-------RQLTEDQSYRISRTI 514

  Fly   400 EPASPSGPSSSSCSSKES-------FNVEVVTPALGCLNLSPAKTIGSMRMASG--TKFVPGHRK 455
            ||.:.|.|:|.....|.:       ...||..|.|....:||:.:..|.....|  :...|
Frog   515 EPPADSCPNSPRIRRKLTKRFSSLLLGSEVFGPKLNGDRVSPSGSCNSCETDDGLISALCP---- 575

  Fly   456 CRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHHLHLE 520
                    ..||..:|..|          ||...               .|..|.|.........
Frog   576 --------NESSTQKNMQE----------PGTPP---------------TTPRHDDQFRFAPRSP 607

  Fly   521 LDPSQVQPRHH--LLDDSVLE------HSDALSQADLTSLESAEGIM 559
            :.||..||.::  :.|..::.      |.:......|||.:.:..::
Frog   608 VSPSSTQPLYNQQIADLCIIRVSMENTHGNMYKSILLTSQDKSRAVI 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	82/274 (30%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rgl3	XP_012808636.1	RasGEF_N	91..191	CDD:366199	13/58 (22%)
		RasGEF	246..517	CDD:214539	83/277 (30%)
		RA_RalGDS_like	623..708	CDD:340449	5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910