DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rapgef5a

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_002665506.2	Gene:	rapgef5a / 100331732	ZFINID:	ZDB-GENE-030131-7681	Length:	615	Species:	Danio rerio

Alignment Length:	404	Identity:	83/404 - (20%)
Similarity:	159/404 - (39%)	Gaps:	51/404 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YSEISRDLSTDNLRYSELSRKPTTDYNGYTGQAYAATQFKQSSPPPPPSQQQQQPTRVSKQRSPN 68
            |.::|...::.:||.|.:..:........:..:|.:.:.|       |:...|:...:..||...
Zfish   255 YQQLSLKENSVSLRASPVESRDVMCRVYVSCDSYLSMRVK-------PAVVAQELLHIVSQRMDR 312

  Fly    69 TNGSAHTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTI 133
            .......:|     :||..   |...:||..|                  .:|.|..:||
Zfish   313 CEDDMMLLA-----QTYSG---EKRVLQPHDS------------------IYSESLVAPG----- 346

  Fly   134 AASAAPPSKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKK 198
            ...|.....|:.||.......|....:..|.:....:|..:|..|:.:|..|...||....::::
Zfish   347 RLIACRRDLSEILPPLTECPDLGQKPVRLLGINTWDVAVALTNFDWNLFNSIHEQELIFYTFSRQ 411

  Fly   199 DKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISA 263
            ....:|..:....:|.|....|.:.|:|......:|.:::..|||:|.......||:|.||||..
Zfish   412 ASSGHTVALEFLLQRCNEVQQWVMSEVLLCPSLSKRVQLLKKFIKIAAHCKAQRNLNSSFAIIMG 476

  Fly   264 MQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYI 328
            :.:|::.||.:||..:..|.:..|..|..:.....|....|...:.::.|.||::.|.|.|:.:|
Zfish   477 LNTAAVSRLNQTWEKVPGKFKKLFSELELLTDPSMNHKAYRDAFKKMKPPKIPFMPLLLKDITFI 541

  Fly   329 DLAHPHKG------GLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNI 387
                 |:|      .|...::.:.:.:.:|:|.:.|.....:......:.:..:|:.|:..:.|
Zfish   542 -----HEGNKTFHDNLVNFEKLHMIADTVRLIRHCQMDQTGNELSAVDSAEVRSSVHYLHIIDN- 600

  Fly   388 FEEDQYKRSLNLEP 401
             ::..::.|..|||
Zfish   601 -QQTLFELSHRLEP 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	53/242 (22%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rapgef5a	XP_002665506.2	RasGEFN	100..237	CDD:214571
rapgef5a	XP_002665506.2	RasGEF	375..615	CDD:214539	56/246 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910