DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and ralgds

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_012823402.1	Gene:	ralgds / 100135084	XenbaseID:	XB-GENE-987988	Length:	856	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	121/471 - (25%)
Similarity:	191/471 - (40%)	Gaps:	104/471 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 CLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSK 142
            ||:|..||....:....::.:|   .|:.:..::..|..|.  ....|...|...:...   |..
Frog   236 CLKQLITYVRHNIPGSDLERRA---CNLLTQFKRQQISALE--PDVVDHTSCTLRLVEE---PLL 292

  Fly   143 SQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDK----HVN 203
            |...|...|.:|             |:||.|.|::|..:|.::.|.....|.|:::||    |:
Frog   293 SDGKPDFLSFRQ-------------DMLAEQFTVMDAELFKKVVPYHCLGCIWSQRDKKGKEHL- 343

  Fly   204 TPNIVAFTKRFNHTSFWTVQEIL--NAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQS 266
            .|.|.|...:||..:...:...|  .:.:|:|||::|..:|:||::...|.|..||.||:||:|.
Frog   344 APTIRATVSQFNSVTNCVISTCLCDRSLKPQQRAKVIERWIEVARECRILKNFSSLRAILSALQC 408

  Fly   267 ASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYL------------------------ 307
            .:|:||.|||..:|::....|..||:||||::|.:..|..|
Frog   409 NAIHRLKKTWDEVSRESYRIFMELSEIFSDENNHSLSRELLIKEGTSKFATLDINPKRAQKRQQQ 473

  Fly   308 ---ESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNILRVISNYQQ--SNYKHL 365
               ..:....|||||.|||||:.:|.|...  :.||...::|.|...::..|...|.  :||..|
Frog   474 QREMGVMQGTIPYLGTFLTDLVMLDTAMKDYLESGLINFEKRRKEFEVIAQIKLLQSACNNYSFL 538

  Fly   366 QKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSG---------------------PSS 409
            ...       :.:.:...::.:.|.:.|..|..:||.|.|.                     |||
Frog   539 PDE-------SFVEWFHSVERLTEAESYSLSCEIEPLSESASNTLKAKKNTGIIKRWSDRQPPSS 596

  Fly   410 SSC----SSKESFNVEVVTPALGC-------LNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKF 463
            ..|    |..:||:....:|.| |       |:::.|.:..|........|||....|:.  .|.
Frog   597 EPCPSVSSHSKSFDQLKCSPHL-CGGDTTDSLSVTSAGSSSSDVDEINISFVPESPDCQE--KKV 658

  Fly   464 R---SSSLPRNFAEKC 476
            |   |.:.|...||.|
Frog   659 REGPSQARPIQPAEPC 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	77/273 (28%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
ralgds	XP_012823402.1	RasGEFN	135..265	CDD:214571	7/31 (23%)
		RasGEF	299..564	CDD:238087	79/285 (28%)
		RA_RalGDS	740..825	CDD:340729
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910