DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rasgrp1

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001093748.2	Gene:	rasgrp1 / 100101791	XenbaseID:	XB-GENE-489811	Length:	811	Species:	Xenopus tropicalis

Alignment Length:	297	Identity:	74/297 - (24%)
Similarity:	121/297 - (40%)	Gaps:	65/297 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDE-----LSSCAWTKKDKHV 202
            :|.:..:.|.|:..:::...|. |.: ||..:|.|:|..|.:|...:     :|.|.       .
Frog   200 TQRIKPNCSKKRKVSLLFDHLE-PQE-LAEHLTYLEFKAFRRISFSDYQNYIVSGCV-------K 255

  Fly   203 NTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSA 267
            ..|.:.......|..|.|....:|:...|:.|||::|.||.||:|||:|.|.::|.|:|..:..:
Frog   256 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHS 320

  Fly   268 SIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAH 332
            ||.||..|.|.:|.......:.::::.|...|:.|.|..........||.||:.|.|||.:..|
Frog   321 SISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEA- 384

  Fly   333 PHKGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNI---------- 387
                  .|:...:...|:.::     .|.|.|:.:             :.:||||
Frog   385 ------MPDFLEDSKINVPKL-----HSLYNHINE-------------LIQLQNIAPPLEANMDL 425

  Fly   388 ------------FEEDQYKRSLNLEP----ASPSGPS 408
                        .|::.|:.|...||    |.|..||
Frog   426 VHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPS 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	65/263 (25%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rasgrp1	NP_001093748.2	REM	77..193	CDD:100121
		RasGEF	217..453	CDD:214539	67/269 (25%)
		EF-hand_7	494..543	CDD:372618
		C1_1	558..607	CDD:365894
		BRLZ	744..799	CDD:197664
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910