Protein Alignment RalGPS and ralgps1

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001093616.1
• Gene: ralgps1 / 100101642
• ZFINID: ZDB-GENE-070720-16
• Length: 581
• Species: Danio rerio
• Alignment Length: 630
• Identity: 234/630 - (37%)
• Similarity: 320/630 - (50%)
• Gaps: 138/630 - (21%)

  Fly   141 SKSQSLPAHA--SIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVN 203
            |.|:||...:  |.|..|||:...|:|..:..|:||||:|.|||..|||:||:||.|.||:||..
Zfish    22 SSSESLDGRSLDSAKSFDAVVFDMLKVTPEEFASQITLMDAPVFKAIQPEELASCGWNKKEKHSL 86

  Fly   204 TPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSAS 268
            :||:||||:|||..|||.|:|||.|:..|.||||:.||||:||||.||||||||.:::||:|||.
Zfish    87 SPNVVAFTRRFNQVSFWAVREILTAQTLKIRAEILGHFIKIAKKLLELNNLHSLVSVVSALQSAP 151

  Fly   269 IYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRL-PCIPYLGLFLTDLIYIDLAH 332
            |:||:||||.:|:||:..|::|..:.|.::|:..:|.|..||:: |||||||::|.|:.|||.|:
Zfish   152 IFRLSKTWALISRKDKATFEKLDFLTSKEENYNRMREYTRSLKMAPCIPYLGIYLFDMTYIDSAY 216

  Fly   333 PHKGG-LEPEQRRNKMNNILRVISNYQQS-NYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKR 395
            |.... :|.|||.|:|||:||:||:.|.| .|.||......||||.|:|||||||...|:|.|..
Zfish   217 PASDSIIETEQRTNQMNNLLRIISDLQVSCKYDHLITLPHVQKYLMSVRYIEELQKFVEDDNYSL 281

  Fly   396 SLNLEPASPS-----------GPSSSSCSSK---------ESFNVEVVTPALGCLNLSPAKTIGS 440
            ||.:||.:.|           |||..|.|.:         .|....:.||       .||:
Zfish   282 SLKIEPGNSSPRLVSSKEDLGGPSEVSMSVRYNRRPTCPDTSVVAHLPTP-------PPAR---- 335

  Fly   441 MRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIA 505
                        |||..|||                              :|..|:...:..|.|
Zfish   336 ------------HRKSHSLG------------------------------NNMMCQFGVVESKSA 358

  Fly   506 THNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLE-HSDALSQA---------DLTSLESA----- 555
            |.               |.:.:.| ||||||.|| ||...:..         .|.|.||:
Zfish   359 TF---------------PEKEKAR-HLLDDSFLESHSPVRNHTHDSVFTNGISLGSRESSFSDEL 407

  Fly   556 -----------------EGIMCDFTGSDCDLMSPEAAAAMHGC-----------VRRKTVQKEGR 592
                             ...||:...|...:.|...|.:.:.|           :||||:.|||:
Zfish   408 SSTVERGRMYATLGPNWRVPMCNSPRSRSYIYSTPGAVSSYECSTLSSITIEGPLRRKTLMKEGK 472

  Fly   593 KPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVSDNTKHKNTFELC 657
            ||.::||:.||:.:..:.|:||..|:.:.:||..:|..|||...|.||...:.||.:|.|.|:|.
Zfish   473 KPTLSSWKCYWIVLSGSILIYFGSKALRANERRHYKSRPCKKITLTGWMVVLPDNPEHPNIFQLT 537

  Fly   658 HRTLGTVYRFRTDSPQMTHLWSNAICKLATMRVPKPLPTNLMSFE 702
            ....|.||:|:|.|.....:|...:.:......|: :|.||||||
Zfish   538 DPDRGNVYKFQTGSRFSAIIWHRHLAEACRSTRPQ-MPANLMSFE 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	96/166 (58%)
		PH_RalGPS1_2	578..692	CDD:270120	40/124 (32%)
ralgps1	NP_001093616.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		4/8 (50%)
		RasGEF	46..289	CDD:214539	134/242 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..339		7/41 (17%)
		PXXP	329..332		2/9 (22%)
		PH_RalGPS1_2	457..572	CDD:270120	39/114 (34%)