DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rapgef5b

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001092249.1	Gene:	rapgef5b / 100073343	ZFINID:	ZDB-GENE-061215-2	Length:	341	Species:	Danio rerio

Alignment Length:	418	Identity:	82/418 - (19%)
Similarity:	135/418 - (32%)	Gaps:	139/418 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 EPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQL 155
            |.||.:....|.|.:..:|                           ..||   :.|...:..|:.
Zfish     6 ESPSFKDLVCKVLEVHKSR---------------------------TDPP---RLLKNGSQFKKN 40

  Fly   156 DAVILSALRVPADVLA-------NQITLLDFPVFAQ-IQPDELSSCA--WTKKDKHVNTPNIVAF 210
            ..||:|....|..:|.       :|..:.:.|...| ::...||:|.  |   ..||....|:
Zfish    41 LEVIISQKPPPDSILCSNAGQTRHQACVNNVPCAGQALRNAVLSNCQDNW---KTHVKLAKII-- 100

  Fly   211 TKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLH-----ELNNLHSLFAIISAMQSASIY 270
              |..:.....|:.:::..:..|..||.:....|...|.     |.||:..        .|.|:|
Zfish   101 --RRTYIGIELVEWLMDHCEFIQNREIASKIWNVLLDLGILLSVEQNNIFE--------DSRSLY 155

  Fly   271 RLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHK 335
            :.|     ..:.:..:.|     |.:|.||   ||.:.            .|..|:      ||:
Zfish   156 QFT-----FKECEAQSCD-----FRNQVNW---RSAVH------------LLLQLV------PHE 189

  Fly   336 ---GGLEPEQRRNKM------NNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEED 391
               ||.:...:.:|.      |.:|::               .|.:.:.::::  .||.......
Zfish   190 QLCGGTQRRCKEDKQKTPDACNPVLQM---------------RALEHFTSTVQ--NELLAALARK 237

  Fly   392 QYKRSLNLEPASP----SGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPG 452
            ...:|: :|.::|    ..|.|||            |||:  |...|..........|..:.|..
Zfish   238 AQTKSM-MEDSNPQHNTDTPGSSS------------TPAV--LKQVPGAGTRDREEISRLEMVQR 287

  Fly   453 HRK--CRSLGTKFRSSSLPRNFAEKCQC 478
            ..|  ||.|.:..|.:..|..|.| |.|
Zfish   288 LAKDGCRLLHSPLRVNERPAEFVE-CIC 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	46/260 (18%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rapgef5b	NP_001092249.1	DEP	74..191	CDD:295306	33/162 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910