DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp53D and POTEI

DIOPT Version :9

Sequence 1:	NP_477037.2	Gene:	Arp53D / 36879	FlyBaseID:	FBgn0011743	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001358855.1	Gene:	POTEI / 653269	HGNCID:	37093	Length:	1097	Species:	Homo sapiens

Alignment Length:	405	Identity:	234/405 - (57%)
Similarity:	296/405 - (73%)	Gaps:	14/405 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IDITNKRAQNILHKYLHLPTSPGNMSSEVDSNSHHAAVVIDNGSGVCKAGFSPEDTPRAVFPSIV 76
            |:...|:..|:| |.|.|        :|:..:...|.:|||||||:|||||:.:|.|||||||||
Human   702 IESVKKKNDNLL-KALQL--------NELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIV 757

  Fly    77 GRPRHLNVLLDSVIGDSVIGEAAARKRGILTLKYPIEHGMVKNWDEMEMVWQHT-YELLRADPMD 140
            ||||...::......:|.:|:.|..||||||||||:|||::.|||:||.:|.|| |..||..|.:
Human   758 GRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEE 822

  Fly   141 LPALLTEAPLNPKKNREKMTEIMFEHFQVPAFYVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPI 205
            .|.||||||||||.||||||:||||.|..||.|||:||:||||.:|||.|||:||||||||||||
Human   823 HPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPI 887

  Fly   206 YEGFALPHACVRVDLAGRDLTDYLCKLLLERGVTMGTSAEREIVREIKEKLCYVSMNYAKEMDLH 270
            |:|.|||||.:|:|||||:|||||.|:|.|||....|.|||||||:||||||||::::.:||.:.
Human   888 YDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMA 952

  Fly   271 GK----VETYELPDGQKIVLGCERFRCPEALFQPSLLGQEVMGIHEATHHSITNCDMDLRKDMYA 331
            ..    .::|||||||.|.:|.|.||||||||||..||.|..||||.|.:||...|:|:|||:|.
Human   953 ASSSSLEKSYELPDGQVITIGNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYT 1017

  Fly   332 NIVLSGGTTMFRNIEHRFLQDLTEMAPPSIRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSL 396
            |.||||||||:..:.||..:::..:||..::|::.|.|.|::|||.|||:||||::||.|||...
Human  1018 NTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQ 1082

  Fly   397 EYEEVGSAIVHRKCF 411
            ||:|.|.:|||||||
Human  1083 EYDESGPSIVHRKCF 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ACTIN	46..411	CDD:214592	224/369 (61%)
Arp53D	NP_477037.2	NBD_sugar-kinase_HSP70_actin	47..411	CDD:302596	224/368 (61%)
POTEI	NP_001358855.1	Ank_2	158..>361	CDD:393464
		ANK repeat	174..203	CDD:293786
		ANK repeat	205..236	CDD:293786
		ANK repeat	238..269	CDD:293786
		ANK repeat	271..302	CDD:293786
		ANK repeat	304..335	CDD:293786
		CCDC144C	670..>723	CDD:373382	8/29 (28%)
		NBD_sugar-kinase_HSP70_actin	723..1097	CDD:388382	224/373 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D283838at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920