Protein Alignment Arp53D and ACTL6B

DIOPT Version :10

• Sequence 1: NP_477037.2
• Gene: Arp53D / 36879
• FlyBaseID: FBgn0011743
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 90/463 - (19%)
• Similarity: 148/463 - (31%)
• Gaps: 135/463 - (29%)

  Fly  1132 ALIKWSETRSQHDKEYDYRYKLRFITQLQD-----KTVPEGSNLKFTCYVDGKFPLFMWYKDDIP 1191
            |:|...|.|    |:.:..::|...|..|.     ..|..|:||....:.:.|..||...||
Human    19 AVISQLEER----KDLENLFQLATGTDSQGLWTECTAVQSGNNLTKEVHEEEKSTLFELQKD--- 76

  Fly  1192 LVQGRKYRQKTRRDGKVTL----EIVNVTTDDAGTYKLEARNYAGSIE--TKSAVTVYENPYTKF 1250
                  :.|:|.......|    ||.:..::.......:.|..|.|:|  ..|........:|..
Human    77 ------FSQETNFSKTYILGQQQEIRSAGSERGSASATDGRAKASSVEGCLFSQTPQLSQDHTSS 135

  Fly  1251 VPPIFASNILATTS--TTETAATTTREESK----SQRTAQLQVSTEMDRTTTTVG-GKR---SQT 1305
            ...:::...|:.:.  |||......||.::    |.:..||....::::...... ||.   ...
Human   136 TGELYSDTKLSKSERITTEERPLKPRELAEASQGSPQVNQLPEICDVEKPYQCAECGKAFSVKAK 200

  Fly  1306 YPYHYRMDT-------------FATTLSRGHDSQLHSSLEMYQPIVQTVLRDRLVKRGSNLLLVC 1357
            :.:|.|:..             |:.:........:||..:.||                     |
Human   201 FVWHQRLHNGEKPFKCVECGKCFSYSSHYITHQTIHSGEKPYQ---------------------C 244

  Fly  1358 SFWGVNCEIEWVHNYTKLSSGAKYRISR-HQGMSILEIYD-----------ITHQEAGM----YK 1406
            ...|....:          :|:..|..| |.|....:..|           ||||....    |:
Human   245 KVCGKAFSV----------NGSLVRHQRIHTGEKPYQCKDCGAGFGCSSAYITHQRTHTGEKPYE 299

  Fly  1407 CVVRNDCGEDVTNCCILVLDHIRLSSTKQTRPDQTYSLHSNEIVLECRVRGTPRPNIAWIKDGEY 1471
            |   :|||: ..|....::.|.|              :|:.|...||.|.|........::..:.
Human   300 C---SDCGK-AFNVNAKLIQHQR--------------IHTGEKPYECDVCGKGFRCSTQLRQHQS 346

  Fly  1472 IIPGDKYEQYDHADGTC--------KLIVTSPGEEDSGTYTCEAESGGCSDAISHNVQFVSKEKV 1528
            |..|:|    .|....|        |||      :....:|.| :...|||.   ...|.:|.|:
Human   347 IHTGEK----PHRCSECGKGFTKNAKLI------QHQRVHTGE-KPYACSDC---GKTFSAKGKL 397

  Fly  1529 LM-ERTHS 1535
            :. :|.|:
Human   398 IQHQRIHT 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ASKHA_ATPase-like	47..406	CDD:483947
ACTL6B	NP_057272.1	ASKHA_NBD_Arp4_ACTL6-like	8..417	CDD:466846	90/463 (19%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		12/51 (24%)