DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp53D and Actl11

DIOPT Version :9

Sequence 1:	NP_477037.2	Gene:	Arp53D / 36879	FlyBaseID:	FBgn0011743	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001019959.2	Gene:	Actl11 / 316000	RGDID:	1310036	Length:	1218	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	143/373 - (38%)
Similarity:	210/373 - (56%)	Gaps:	38/373 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 AAVVIDNGSGVCKAGFSPEDTPRAVFPSIV--------GRPRHLNVLLDSVIGDSVIGEAAARKR 103
            ||:|||.|:|..|.|.:.|:...:|.||.|        |:|::       |:.:...|..:...|
  Rat   870 AAIVIDTGTGFTKCGLAQENHVLSVVPSQVQMLQHPPQGQPQY-------VVPEHQEGSYSVLNR 927

  Fly   104 GILTLKYPIEHGMVKNWDEMEMVWQHT-YELLRADPMDLPALLTEAPLNPKKNREKMTEIMFEHF 167
            |:           |.:||.:|::|||. |..||..|.::..|:.::|::|:.||||:.||:||.|
  Rat   928 GV-----------VSDWDALEVLWQHLFYCKLRVQPEEMAVLVADSPISPRTNREKVAEILFERF 981

  Fly   168 QVPAFYVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYLCKL 232
            .|||.....||:|:|||.|||.|:||.||.|.::..||..|...|....|:|:||.||||||.:|
  Rat   982 HVPAMQTVHQALLTLYAYGRTTGLVVGSGHGTSYVAPIITGDLAPLDTYRLDVAGADLTDYLAQL 1046

  Fly   233 LLERGVTMGTSAEREIVREIKEKLCYVSMNYAKEMDLH-GKVET-YELPDGQKIVLGCERFRCPE 295
            |:..|   .:..:..|||:|||..|||:|:...||..: .:|:. :.|||...|.||.|||.|||
  Rat  1047 LMSGG---HSPPKGGIVRQIKEACCYVAMDTTTEMARNQSQVQVDFVLPDKHVITLGSERFCCPE 1108

  Fly   296 ALFQPSLLGQEVMGIHEATHHSITNCDMDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTEMAPPS 360
            |||||:|||...:|:.:....||:..::..::.:.||:||.||:|:......|..|:|...|
  Rat  1109 ALFQPNLLGLNQLGLPQLALLSISRLEVKQQEQLLANVVLEGGSTLINGFPERMRQELGPGA--- 1170

  Fly   361 IRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHR 408
               .|..||.|..:.|.|||::|...|||::|:...||||.|...:::
  Rat  1171 ---TVLGSPHRAVAAWLGGSIMACRDSFQSLWLSRREYEEEGPWAIYK 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ACTIN	46..411	CDD:214592	143/373 (38%)
Arp53D	NP_477037.2	NBD_sugar-kinase_HSP70_actin	47..411	CDD:302596	143/373 (38%)
Actl11	NP_001019959.2	PHA03247	<200..485	CDD:223021
Actl11	NP_001019959.2	NBD_sugar-kinase_HSP70_actin	871..1215	CDD:418402	142/370 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100