DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp53D and Actl7b

DIOPT Version :9

Sequence 1:	NP_477037.2	Gene:	Arp53D / 36879	FlyBaseID:	FBgn0011743	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001020588.1	Gene:	Actl7b / 313183	RGDID:	1305655	Length:	417	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	153/377 - (40%)
Similarity:	223/377 - (59%)	Gaps:	25/377 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AVVIDNGSGVCKAGFSPEDTPRAVFPSIVGRPRHLNVLLDSVIGD----SVIGEAAARKRGILTL 108
            |:|||.||..||.|::.|..|.....|.||: |...:..|:  ||    :.:|.........|.|
  Rat    52 ALVIDLGSQYCKCGYAGEPRPTYFISSTVGK-RSAEMAADA--GDTFKETYVGHELLNMEASLKL 113

  Fly   109 KYPIEHGMVKNWDEMEMVWQHTYE-LLRADPMDLPALLTEAPLNPKKNREKMTEIMFEHFQVPAF 172
            ..|::||:|.:||.::.:|::.:. .::..|.:...|:::.||:|..||||..|:|||.|.:||.
  Rat   114 VNPLKHGVVVDWDCIQNIWEYIFHTAMKILPEEHAVLVSDPPLSPTSNREKYAELMFETFGIPAM 178

  Fly   173 YVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYLCKLLLERG 237
            :|..||:||:|:.|:|.|:||:||.||:|.|||.||..||....|||.||.|||:||.:||.|.|
  Rat   179 HVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAG 243

  Fly   238 VTMGTSAEREIVREIKEKLCYVSMNYAKEM-----DLHGKVETYELPDGQKIVLGCERFRCPEAL 297
            ... :.....|:..||:|.||.::...:||     :||   ..||||||:.|.:|.|||||.|.|
  Rat   244 HKF-SDDHLHIIEHIKKKCCYAALLPEEEMSLGLDELH---VDYELPDGKVITIGQERFRCSEML 304

  Fly   298 FQPSLLGQEVMGIHEATHHSITNCD-MDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTEMAP--- 358
            |:|||:|....|:.|.|...:..|. ...:::|.||::|.||.||......||.::|:.:.|
  Rat   305 FKPSLVGSTQPGLPELTATCLDRCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDS 369

  Fly   359 PSIRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHRKC 410
            |:    |.|:|:|:.|||||||:||||.:||.:|:...|:||.|.|.::.||
  Rat   370 PT----VAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSKC 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ACTIN	46..411	CDD:214592	153/377 (41%)
Arp53D	NP_477037.2	NBD_sugar-kinase_HSP70_actin	47..411	CDD:302596	153/377 (41%)
Actl7b	NP_001020588.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
Actl7b	NP_001020588.1	ACTIN	51..417	CDD:214592	151/375 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100