DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp53D and Acta2

DIOPT Version :9

Sequence 1:	NP_477037.2	Gene:	Arp53D / 36879	FlyBaseID:	FBgn0011743	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_031418.1	Gene:	Acta2 / 11475	MGIID:	87909	Length:	377	Species:	Mus musculus

Alignment Length:	381	Identity:	240/381 - (62%)
Similarity:	295/381 - (77%)	Gaps:	9/381 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MSSEVDSNSHHAAVVIDNGSGVCKAGFSPEDTPRAVFPSIVGRPRHLNVLLDSVIGDSVIGEAAA 100
            |..|.||    .|:|.|||||:|||||:.:|.||||||||||||||..|::.....||.:|:.|.
Mouse     1 MCEEEDS----TALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQ 61

  Fly   101 RKRGILTLKYPIEHGMVKNWDEMEMVWQHT-YELLRADPMDLPALLTEAPLNPKKNREKMTEIMF 164
            .||||||||||||||::.|||:||.:|.|: |..||..|.:.|.||||||||||.||||||:|||
Mouse    62 SKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMF 126

  Fly   165 EHFQVPAFYVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYL 229
            |.|.|||.|||:||||||||:|||.|||:||||||||.||||||:|||||.:|:|||||||||||
Mouse   127 ETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYL 191

  Fly   230 CKLLLERGVTMGTSAEREIVREIKEKLCYVSMNYAKEM----DLHGKVETYELPDGQKIVLGCER 290
            .|:|.|||.:..|:|||||||:||||||||::::..||    ......::|||||||.|.:|.||
Mouse   192 MKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNER 256

  Fly   291 FRCPEALFQPSLLGQEVMGIHEATHHSITNCDMDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTE 355
            |||||.|||||.:|.|..||||.|::||..||:|:|||:|||.||||||||:..|..|..:::|.
Mouse   257 FRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITA 321

  Fly   356 MAPPSIRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHRKCF 411
            :||.:::||:.|.|:|::|||.|||:||||::||.|||...||:|.|.:|||||||
Mouse   322 LAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ACTIN	46..411	CDD:214592	234/369 (63%)
Arp53D	NP_477037.2	NBD_sugar-kinase_HSP70_actin	47..411	CDD:302596	234/368 (64%)
Acta2	NP_031418.1	PTZ00281	3..377	CDD:173506	237/377 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54227
OrthoDB	1	1.010	-	-		D283838at33208
OrthoFinder	1	1.000	-	-		FOG0000057
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930