DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp53D and Actl7a

DIOPT Version :9

Sequence 1:	NP_477037.2	Gene:	Arp53D / 36879	FlyBaseID:	FBgn0011743	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_033741.1	Gene:	Actl7a / 11470	MGIID:	1343051	Length:	440	Species:	Mus musculus

Alignment Length:	376	Identity:	144/376 - (38%)
Similarity:	220/376 - (58%)	Gaps:	23/376 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AVVIDNGSGVCKAGFSPEDTPRAVFPSIVGRPRHLNVLLDSVIGD----SVIGEAAARKRGILTL 108
            |||:|.|:|.||.||:....|.....:.||:|    .:..:..||    :.:|.........|.|
Mouse    76 AVVVDLGTGFCKCGFAGLPKPTHKISTTVGKP----YMETAKTGDNRKETFVGHELFNPDIHLKL 136

  Fly   109 KYPIEHGMVKNWDEMEMVWQHTY-ELLRADPMDLPALLTEAPLNPKKNREKMTEIMFEHFQVPAF 172
            ..|:.||::.:||.::.:|::.: :.::..|.:...|:::.||:|..||||..|::||.|..||.
Mouse   137 VNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAM 201

  Fly   173 YVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYLCKLLLERG 237
            ::|.|:.||:|:.|||.|:||:.|.||::.||||||:.||....|:|.||.|||.||..|:...|
Mouse   202 HIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSG 266

  Fly   238 VTMGTSAEREIVREIKEKLCYVSMN-------YAKEMDLHGKVETYELPDGQKIVLGCERFRCPE 295
            ... :.....||.:||.:.|:|:::       .|.|.::|     |.||||::|.||.|||.|.|
Mouse   267 KHF-SEDHLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIH-----YTLPDGKEIRLGQERFLCSE 325

  Fly   296 ALFQPSLLGQEVMGIHEATHHSITNCDMDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTEMAPPS 360
            ..|:|||:....:|:|..|...:..||:.|::|:..||:|.||:||.|...:|..::|:.|.|..
Mouse   326 MFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPND 390

  Fly   361 IRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHRKCF 411
            .. :||..|:|..:||||||:||||..||.:|:..|||||.|...::|:||
Mouse   391 TP-QVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ACTIN	46..411	CDD:214592	142/374 (38%)
Arp53D	NP_477037.2	NBD_sugar-kinase_HSP70_actin	47..411	CDD:302596	142/374 (38%)
Actl7a	NP_033741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		ACTL7A_N	6..70	CDD:293445
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	142/374 (38%)
		ACTIN	74..440	CDD:214592	142/374 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010