DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp53D and ACTL7A

DIOPT Version :9

Sequence 1:	NP_477037.2	Gene:	Arp53D / 36879	FlyBaseID:	FBgn0011743	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_006678.1	Gene:	ACTL7A / 10881	HGNCID:	161	Length:	435	Species:	Homo sapiens

Alignment Length:	371	Identity:	143/371 - (38%)
Similarity:	219/371 - (59%)	Gaps:	13/371 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AVVIDNGSGVCKAGFSPEDTPRAVFPSIVGRPRHLNVLLDSVIGD----SVIGEAAARKRGILTL 108
            |||:|.|:|.||.||:....|.....:.||:|    .:..:..||    :.:|:........|.|
Human    71 AVVVDLGTGYCKCGFAGLPRPTHKISTTVGKP----YMETAKTGDNRKETFVGQELNNTNVHLKL 131

  Fly   109 KYPIEHGMVKNWDEMEMVWQHTY-ELLRADPMDLPALLTEAPLNPKKNREKMTEIMFEHFQVPAF 172
            ..|:.||::.:||.::.:|::.: :.::..|.:...|:::.||:|..||||..|::||.|..||.
Human   132 VNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFEAFNTPAM 196

  Fly   173 YVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYLCKLLLERG 237
            ::|.|:.||:|:.|||.|:||:.|.||::.||||||:.||....|:|.||.|||.||..||...|
Human   197 HIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLLGLLNSAG 261

  Fly   238 VTMGTSAEREIVREIKEKLCYVSMN--YAKEMDLHGKVETYELPDGQKIVLGCERFRCPEALFQP 300
            ... |..:..||.:||:|.|:|:::  ..|::.|......|.||||::|.|..|||.|.|..|:|
Human   262 NEF-TQDQMGIVEDIKKKCCFVALDPIEEKKVPLSEHTIRYVLPDGKEIQLCQERFLCSEMFFKP 325

  Fly   301 SLLGQEVMGIHEATHHSITNCDMDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTEMAPPSIRIKV 365
            ||:....:|:|..|...:..||:.|::|:..||:|.||:||.....:|..::|:.|.|.... :|
Human   326 SLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTP-QV 389

  Fly   366 NASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHRKCF 411
            |..|:|..:||||||:||||..||.:|:...||||.|...::|:||
Human   390 NVLPERDSAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp53D	NP_477037.2	ACTIN	46..411	CDD:214592	141/369 (38%)
Arp53D	NP_477037.2	NBD_sugar-kinase_HSP70_actin	47..411	CDD:302596	141/369 (38%)
ACTL7A	NP_006678.1	ACTL7A_N	1..65	CDD:293445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		Required for interaction with TES	31..51
		NBD_sugar-kinase_HSP70_actin	67..435	CDD:302596	141/369 (38%)
		ACTIN	69..435	CDD:214592	141/369 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010