DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and SLC24A1

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_004718.1	Gene:	SLC24A1 / 9187	HGNCID:	10975	Length:	1099	Species:	Homo sapiens

Alignment Length:	688	Identity:	133/688 - (19%)
Similarity:	234/688 - (34%)	Gaps:	208/688 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 FIALFVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVER 146
            ::.|.|.....:.|.|....:.|:.|||..::..|.::|.:||.|.||.|.::.:.|.:|
Human   454 WVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSL----- 513

  Fly   147 HVPVFANN--------LSSALFVITISGGLIFYISPFKMNSYETV--------RDILFLLLATLL 195
             :.||.::        :.||:|      .::|.|....:.|.|.:        ||:.|.:|..::
Human   514 -IGVFISHSNVGIGTIVGSAVF------NILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIM 571

  Fly   196 MDYFAYTTNHFALGYEFKFFIVLLVYISYIII----NVADVYLLQKTIASTRTKMQKLLDEKQTP 256
            :..|...    :|...::..::||.|..|:..    ...:|::.::.......|:..|.|..:..
Human   572 LILFFLD----SLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPG 632

  Fly   257 EIALKLQDLE--RKLEYYSQDTRVEILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDY 319
            :.|:.:.:|:  :||:..|..||.   ..|:|:..:.||.|..:::.:....:  |..|..|...
Human   633 DGAIAVDELQDNKKLKLPSLLTRG---SSSTSLHNSTIRSTIYQLMLHSLDPL--REVRLAKEKE 692

  Fly   320 TQSKNQGIFRDFFLALRPIKCQAWKQAELLNRVLLLIRAPAVVICTLYIPLV------------- 371
            .:|.|||           .:.|...:||.........:.|||.:....:|.:
Human   693 EESLNQG-----------ARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQED 746

  Fly   372 -----------------------------------DYEMEKHGWNKLLNAIN------------- 388
                                               :.|.|..|..:.....|
Human   747 VAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDE 811

  Fly   389 ---------VVVNPALSISIFLSFMH--------------------------------------- 405
                     :..|...:.|..||..:
Human   812 GEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEE 876

  Fly   406 -------------RKGN-----FLWYISLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWV 452
                         .|||     ..|..:.|...||   .|:|.:   ||.|:....||.......
Human   877 EQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIY---LFLLPI---VFPLWLTVPDVRRQESRK 935

  Fly   453 FTIMNLTGSMFLIFLCATEIDTVLEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPK 517
            |.:....||:..|.:.:..:......:|..:.|.:..||.|:.|...::..|..:..||..|...
Human   936 FFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD 1000

  Fly   518 MAFASAIGGSFFTIVVTGNTVAYVR-SLVGNRSEHHMEEYG---EIAFIFLNMALFTI-----LL 573
            ||.:|::|.:.|.|.| |..|.::. ||:.......:...|   .|..:|| |.||.|     ..
Human  1001 MAVSSSVGSNIFDITV-GLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFL-MLLFVISSIASCK 1063

  Fly   574 W--STTLGFFARRSMGLYSIGLYVVYLLFVTLVHEEVI 609
            |  :..|||    :|.|    ||.|:|:...::.:.:|
Human  1064 WRMNKILGF----TMFL----LYFVFLIISVMLEDRII 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	27/115 (23%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	42/155 (27%)
SLC24A1	NP_004718.1	2A1904	1..1099	CDD:273344	133/688 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..150
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..304
		Alpha-1	494..534		12/45 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..901		22/221 (10%)
		Alpha-2	979..1010		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810