DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5348 and Slc24a2

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_113931.1	Gene:	Slc24a2 / 84550	RGDID:	628650	Length:	670	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	114/583 - (19%)
Similarity:	228/583 - (39%)	Gaps:	110/583 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 IALFVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASV-ER 146
            |.|.|.....:.:.|....:.::.|:|..::..|.:::.:||.|.||.|.::.:.|.:|..| ..
  Rat   136 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIA 200

  Fly   147 HVPV-FANNLSSALFVITISGGL--IFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFAL 208
            |..| ....:.||:|.|....|:  :|......:..:...||:.|.::..:::  ..:..::..:
  Rat   201 HSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIML--IIFFLDNVIM 263

  Fly   209 GYEFKFFIVLLVYISYIIINVADVY-------------LLQKTIASTRTKMQKLLDEKQTPEIAL 260
            .:|  ..::|..|.:|::....:|.             :::.|::..:.|.....| |:.|.:..
  Rat   264 WWE--SLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKVTVSEAQAKASTAGD-KEEPTLPN 325

  Fly   261 KLQDLERKLEYYSQDTRVEILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQS-KN 324
            |              .|::....|:|:..:.:|.:..:::.:....:........||.|..: ..
  Rat   326 K--------------PRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTE 376

  Fly   325 QGIFRDFFLALRPI---KCQA---WKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKL 383
            :|.||:....|..|   |||.   .:|....|.                   |||..||   .:|
  Rat   377 EGRFREKASILHKIAKKKCQVDENERQNGAANH-------------------VDYAAEK---IEL 419

  Fly   384 LNAINVVVNPALSISIFLSFMHRKGNFLWYISLQN----------------TLIYGAS-----SF 427
            .|:.:..|.  ::.|...|...:.||....|...:                :|.:.::     :|
  Rat   420 PNSTSTEVE--MTPSSEASEPVQNGNLSHSIEAADAPQATETAEEDDDQPLSLSWPSNTRKQITF 482

  Fly   428 VLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVIGNILSIDDNYMGA 492
            ::.:|. ||.|:....||.......|..:...||:..|.:.:..:......:|..:.|.:..||.
  Rat   483 LIVLPI-VFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGL 546

  Fly   493 TVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGNTVAYVRSLVGNR------SEH 551
            |:.|...::..|..:..||..|...||.:|::|.:.|.|.| |..:.::...:.:|      |.:
  Rat   547 TILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITV-GLPLPWLLYTIIHRFKPVTVSSN 610

  Fly   552 HMEEYGEIAFIFLNMALFTIL-----LWSTTLGFFARRSMGLYSIGLYVVYLLFVTLVHEEVI 609
            .:  :..|..:|: |.:|.||     .|.      ..:.:|....|||..:|:...|:.::|:
  Rat   611 GL--FCAIVLLFI-MLIFVILSIALCKWR------MNKILGFIMFGLYFAFLVVSVLLEDKVL 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	23/103 (22%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	35/155 (23%)
Slc24a2	NP_113931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..86
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122
		TIGR00367	138..652	CDD:273039	110/567 (19%)
		Na_Ca_ex	139..281	CDD:279963	29/145 (20%)
		Alpha-1	175..215		13/39 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..335		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..414		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..471		0/20 (0%)
		Na_Ca_ex	507..658	CDD:279963	36/160 (23%)
		Alpha-2	550..581		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810