DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and CCX4

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_564650.1	Gene:	CCX4 / 841851	AraportID:	AT1G54115	Length:	644	Species:	Arabidopsis thaliana

Alignment Length:	653	Identity:	145/653 - (22%)
Similarity:	253/653 - (38%)	Gaps:	157/653 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TVSCFAANNF-PFEERCEFVQKAEDCNSSTNVIPYMRLLACDLKCINQFQEMIFIALFVAFCFQI 93
            ||||...:.. .:.::|||::....| |......|::...|..:   .|:.:.:|.|.|     .
plant    88 TVSCSGLHEHRGYADQCEFLKSNPIC-SPDGFFDYLKFFYCSCR---DFKILGYILLGV-----W 143

  Fly    94 LVLLIY----TINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVPVFANN 154
            ||.|.|    |...|:..:|:.:|:.|.:...:|||||:..||.:.|.||::|:       |..:
plant   144 LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAA-------FVGS 201

  Fly   155 ----------LSSALFVITISGGLIFYI---SPFKMNSYETVRDILFLLLATLLMDYFAYTTNHF 206
                      |..|:||..:..|::...   ...|::....:||:.|.|. ||:...........
plant   202 DKGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVKIDKKCFIRDLSFFLF-TLVALMVILMVGKV 265

  Fly   207 ALGYEFKFFIVLLVYISYIIINVADVYLLQKTIASTRTKMQKLLDEKQTPEIALK-----LQDLE 266
            .:|....|..:.:.|.|.:..|    .:|:|  .|.|.|:..:     ||.:.::     ...:|
plant   266 TVGIAIAFVSIYVFYASLVAAN----EILRK--HSRRLKLDSI-----TPLLPMQGSVFSSPSVE 319

  Fly   267 RKLEYYSQDTRVEILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDF 331
            ..:..||     .::|..:.....|:..:..:.:....|::...:.....:...:....|...|
plant   320 EDIPMYS-----PLMELDTGEGPPRLHDSLPQWMWATNVAIYSNHFAKANVHDEERPPWGWTED- 378

  Fly   332 FLALRPIKCQAWKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALS 396
                     .|..::.|.:::..|:..|..|...|.|||:    |:..|:|.....:|.:.|.|
plant   379 ---------GAEVESSLCSKITSLLETPLTVPRRLTIPLI----EEDSWSKTYAVASVSLAPVL- 429

  Fly   397 ISIFLSFMHRK-------------------GNFLWYISLQNTLIYGASSFVLTVPFAVFILFHAR 442
                |||:...                   |:.|.|::.:||                      .
plant   430 ----LSFLWSSQDDTSLQARIVAYFIGIAIGSTLGYLAFKNT----------------------E 468

  Fly   443 TDVPPSYH---WVFTIMNLTG---SMFLIFLCATEIDTVLEVIGNILSIDDNYMGATVKAFTGNL 501
            .|.||..:   ||     |.|   |:...::.|.|:..:|...|.|..|:.:.:|.||.|:..::
plant   469 PDRPPQIYLIPWV-----LGGFIMSIVWFYMIANELVALLVTFGGIYGINPSILGLTVLAWGNSM 528

  Fly   502 GTLFANTAVAIHGYP--KMAFASAIGGSFF-TIVVTGNTV---AYVRSLVGNRSEHHMEEYGEIA 560
            |.|.:|.|::::|..  ::|.:....|..| |:|..|.::   |:.:|     .|.:|.......
plant   529 GDLVSNIALSMNGGDGVQIALSGCYAGPMFNTLVGLGMSMFLGAWSKS-----PETYMIPEDNSL 588

  Fly   561 FIFLNMALFTILLWSTTLGFFARRSM---GLYSIGLYVVYLLFVTLVHEEVIHSFSDDIQVKSAF 622
            |..|...:|. |:||  |....|..|   .:..|||..:||:|||             .::.||.
plant   589 FYTLGFLIFG-LIWS--LVMLPRNEMRPNKVMGIGLITLYLIFVT-------------FRLSSAM 637

  Fly   623 GDI 625
            |.|
plant   638 GFI 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	29/116 (25%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	44/156 (28%)
CCX4	NP_564650.1	PLN03151	1..644	CDD:215604	145/653 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D478735at2759
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm1105
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790