DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and CAX11

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_172370.3	Gene:	CAX11 / 837416	AraportID:	AT1G08960	Length:	546	Species:	Arabidopsis thaliana

Alignment Length:	592	Identity:	138/592 - (23%)
Similarity:	235/592 - (39%)	Gaps:	143/592 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VQKAEDCNSSTN-----VIPYMRLLACDLKCINQFQEMIFIALFVAFCFQILVL-----LIYTIN 102
            |.....|.||.:     ||.|..|..|      .|.|.:|.::.:   ..:|:|     ||.|..
plant    57 VNPKSSCVSSRSHDNGGVINYFSLHYC------IFNENLFFSIPI---LSLLILLHFYILIKTAQ 112

  Fly   103 VYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVE--RHVPVFANNLSSALFVIT-I 164
            .::|.....::..|:::..:|.|||:|.||.:.|.||::|::.  ::...|...||:..||.. :
plant   113 THFSTVTTKLADRLNLSPSMAAVTLLALGNGAPDVFASVAALRGGQYRTGFGAILSAGTFVSAFV 177

  Fly   165 SGGLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHF----ALGYE--FKFFIVLLVYIS 223
            .|.:..|.:||.:::...|||:||.|:|.|.: ::.|.:...    |:|:.  :.||:..:.::.
plant   178 VGFVAIYAAPFPVDAASFVRDVLFYLIAALFL-FYVYLSGEIFVWQAIGFVGFYIFFVGFVFWMD 241

  Fly   224 YIIINVADVYLLQKTIASTRTKMQKLLDEKQTPEIALKLQDLE---RKLEYYSQDTRVEILEKSS 285
            :                .|..:..|.:.|::  :..|:|||.|   ..|..|.       .||..
plant   242 F----------------GTNVEKGKSISEEE--KDLLRLQDCEIAAGSLGSYK-------AEKEH 281

  Fly   286 SISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDFFLALRPIKCQAWKQAELLN 350
            ..|                                     ||||                  |..
plant   282 QFS-------------------------------------GIFR------------------LYG 291

  Fly   351 RVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSF--MHRKGNFLW- 412
            .:..:...|..|:..|.||    :.....|::...:.|:|..|...:....||  ::...:||:
plant   292 TISRMWETPVSVLLNLTIP----KPSPSEWSRFYRSANIVFCPFALLYTCNSFVQLNHPISFLFP 352

  Fly   413 --YISLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTV 475
              ::.|...:::..||.       .|:.|......|.:......::....|:|.|...|.|:...
plant   353 NTHLPLWLVVLFMTSSL-------AFLHFTVEKQPPKTEQLPVIVVAFIMSVFWISTIAGELLNC 410

  Fly   476 LEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVV-TGNTVA 539
            |..:|.:|.:....:|.||.|:..::|.|.|:.|||..|.|.||.|....|..|.::| .|:
plant   411 LAALGTLLKLPPALLGLTVLAWGNSVGDLVADVAVAKAGRPAMAMAGCFAGPMFNMLVGLGS--- 472

  Fly   540 YVRSLVGNRSEHHMEEYG-------EIAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGLYVVY 597
               :||...:..:.:.|.       .|||:||.::|...||..|...|...|..|:..:||||.:
plant   473 ---ALVMQTANVYPDAYKLGFHVGIVIAFVFLLLSLMGSLLVITWSRFRVPRFWGICLVGLYVAF 534

  Fly   598 LLFVTLV 604
             .||:|:
plant   535 -TFVSLI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	29/107 (27%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	48/152 (32%)
CAX11	NP_172370.3	PLN03151	72..539	CDD:215604	133/574 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D478735at2759
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm1105
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.790