Protein Alignment CG5348 and SLC8B1

DIOPT Version :9

• Sequence 1: NP_611156.3
• Gene: CG5348 / 36877
• FlyBaseID: FBgn0034156
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001345274.1
• Gene: SLC8B1 / 80024
• HGNCID: 26175
• Length: 584
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 144/622 - (23%)
• Similarity: 253/622 - (40%)
• Gaps: 134/622 - (21%)

  Fly    31 VSCFAANNFPFEERCEFVQKAEDCNSSTNVIPYMRLLACDLKCINQFQEMIF---IALFVAFCFQ 92
            |.|.........:||:|::...||:|....:.|:..:.|      .|...:.   :.|:|::...
Human    51 VDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFC------HFPPSLLPLAVTLYVSWLLY 109

  Fly    93 ILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVPVFANNLSS 157
            :.::|..|...::.|.|.|:|..|.::.::||||.:||||.:.|.|:.|.:...  |..|.....
Human   110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSD--PHTAGLALG 172

  Fly   158 ALF-----VITISGGLIFYISPFKMNSYETVRDILFLLLA---TLLMDYFAYTTNHFALGYEFKF 214
            |||     |.|:..|.|..:.||...|....|||:|.::|   |.||.:....|..:||||
Human   173 ALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGY---- 233

  Fly   215 FIVLLVYISYIIINVADVYLLQKTIASTRTKMQKLLDEKQTPEIALKLQDLE------------- 266
               |.:|:.|::..:...::.|:     :.:.........||||   |.|.|
Human   234 ---LGLYVFYVVTVILCTWIYQR-----QRRGSLFCPMPVTPEI---LSDSEEDRVSSNTNSYDY 287

  Fly   267 ----RKLEYYSQDTRVEILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGI 327
                |.|.:| |:|..:||.:
Human   288 GDEYRPLFFY-QETTAQILVR-------------------------------------------- 307

  Fly   328 FRDFFLALRPIKCQAWKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVN 392
                  ||.|:....|::.....:.|.:.:.|...:..|.:|:||.:.:...|.:.||.:::|::
Human   308 ------ALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVIS 366

  Fly   393 PALSISIFLSFMHRKGNFLWYISLQNTLIYGASSFVLTVPFAVFIL----------FHARTD-VP 446
            |.:.:                ::||:. .||.......||..|.::          |.|.:| .|
Human   367 PLVVV----------------LTLQSG-TYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQP 414

  Fly   447 PSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVA 511
            |..||:|..:....|...|...|||:..:|..:|.:..:.:..:|.|:.|:..::|..|::..:|
Human   415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLA 479

  Fly   512 IHGYPKMAFASAIGGSFFTIVVTGNTVAYVRSLVGNRSEHHMEEYGEIAFIF---LNMALFTILL 573
            ..|||:|||::..||..|.|:| |..:..:..:..:.:|..:|..|.:.::.   |.::|...|:
Human   480 RQGYPRMAFSACFGGIIFNILV-GVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLV 543

  Fly   574 WSTTLGFFARRSMGLYSIGLYVVYLLFVTLVHEEVIH 610
            ......|...|..|...:..|:.:|:...|....|||
Human   544 SVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIH 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	32/104 (31%)
		Na_Ca_ex	458..603	CDD:279963	36/147 (24%)
SLC8B1	NP_001345274.1	Na_Ca_ex	63..584	CDD:332332	142/610 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147885
Domainoid	1	1.000	64	1.000	Domainoid score	I10105
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4029
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm40494
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910