DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and SLC24A3

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_065740.2	Gene:	SLC24A3 / 57419	HGNCID:	10977	Length:	644	Species:	Homo sapiens

Alignment Length:	642	Identity:	119/642 - (18%)
Similarity:	217/642 - (33%)	Gaps:	233/642 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CDLKCINQFQEMIF---------IALFVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAG 124
            |....:::|...||         :.|.|.....:...|....:.::.|:|:.:...||::|.:||
Human    87 CTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAG 151

  Fly   125 VTLMAFGNTSADFFANLASVERHVPVFANN--------LSSALF----VITISGGLIFYISPFKM 177
            .|.||.|:::.:.|.::      :.||...        :.||:|    :|.:.|  :|......:
Human   152 ATFMAAGSSAPELFTSV------IGVFITKGDVGVGTIVGSAVFNILCIIGVCG--LFAGQVVAL 208

  Fly   178 NSYETVRDILFLLLATLLMDYFAYTTNHFALGYEFKFFIVLLVYISYIIINVADVYLLQKTIAST 242
            :|:..:||.::..|:.:.:..|.|...   :.: ::..:::|:|:.||:|...:..:.|  ....
Human   209 SSWCLLRDSIYYTLSVIALIVFIYDEK---VSW-WESLVLVLMYLIYIVIMKYNACIHQ--CFER 267

  Fly   243 RTK-----MQKLLDEKQTPE--------IALKLQDLERKLEYYSQDTRVEIL-----EKSSSISI 289
            |||     :..|.:..:..:        :.||..:..||......|   |:|     :.|.|.:.
Human   268 RTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVD---ELLSAYPHQLSFSEAG 329

  Fly   290 TRIRYTT-----MRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDFFLALR-PIK--------- 339
            .||..|:     .|:....|:.:|.|........||..:::       :|:: |||
Human   330 LRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESE-------VAIKIPIKHTVENGTGP 387

  Fly   340 -----------------CQAWKQAE-------------------------------LLNRVLLLI 356
                             .:|..:.|                               .|..|....
Human   388 SSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAF 452

  Fly   357 RAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFMHRKGNFLWYISLQNTLI 421
            ..|...:....:|    ...|..|.|                             |:      ::
Human   453 TWPLSFVLYFTVP----NCNKPRWEK-----------------------------WF------MV 478

  Fly   422 YGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVIGNILSID 486
            ..|||.:....|:..::            |:.||                       ||..|.|.
Human   479 TFASSTLWIAAFSYMMV------------WMVTI-----------------------IGYTLGIP 508

  Fly   487 DNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGNTVAYVRSLVGNRSEH 551
            |..||.|..|...::....|:..||..|...||.:::||.:.|.|::.......:::|.
Human   509 DVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLA------ 567

  Fly   552 HMEEYGEIAFIFLNMALFTILLWSTTLGFFARRSMGL-YSIGLYVVYLLFVTL--VH 605
              .:||  ::|.||                   |.|| ||:|| ::..:|||:  ||
Human   568 --VDYG--SYIRLN-------------------SRGLIYSVGL-LLASVFVTVFGVH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	24/111 (22%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	34/145 (23%)
SLC24A3	NP_065740.2	TIGR00367	112..605	CDD:273039	115/617 (19%)
		Na_Ca_ex	113..255	CDD:279963	32/153 (21%)
		Alpha-1	149..189		11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..442		2/36 (6%)
		Na_Ca_ex	475..627	CDD:279963	45/197 (23%)
		Alpha-2	518..549		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810