DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and CG14743

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	188/607 - (30%)
Similarity:	321/607 - (52%)	Gaps:	30/607 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NFWKTVSCFAANNFPFEERCEFVQKAEDCNSSTNVIPYMRLLACDLKCINQFQEMIFIALF-VAF 89
            :|.:.|||.|..:|.:..|||...|.:||...||...|..::.|..|..|:..|::.:.|| :.:
  Fly    19 DFMQNVSCLAVMHFSYLHRCEMATKIDDCKYITNFFNYYVMMYCSFKIDNKITEIVVMLLFALIY 83

  Fly    90 CFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVPVFANN 154
            || .|.:|...:|.|::|.||..:..:.:||::|||.|:...|::.|...||:.|......|...
  Fly    84 CF-FLCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLLVNLSPVRMEGLTFNIA 147

  Fly   155 LSSALFVITISGGLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFALGYEFKFFIVLL 219
            :::||.:|.:|||.:.:|.||:||.:...||:|||||...|:.:|   .|..||....|..|:|.
  Fly   148 MANALTIICLSGGAVCFIRPFRMNGHSIFRDLLFLLLIIELVRFF---MNDTALAPWIKGAILLS 209

  Fly   220 VYISYIIINVADVYLLQKTIASTRTKMQKLLDEKQTPEIALKLQDLERKLEYYSQDTRVEILEKS 284
            :|..|::||:.|:.||:..|...|..::.|.....:.|..|.|.:...:|....||..::|||.
  Fly   210 IYPIYLLINIVDLILLRYAIRKLRADIEVLRQSPSSREHDLILTEKIVRLNNLQQDDEIQILES- 273

  Fly   285 SSISITRIR-------YTTMRMIRNPRVSV--NRRYTRNMKLDYTQSKNQGIFRDFFLALRPIKC 340
               .:.|.|       .|...:|.:..|.|  |||...:.    ...||..:|.:|..|:.||..
  Fly   274 ---KLYRKRTYNAGFFVTPKPLIHHKEVDVETNRRILHSK----ANPKNLFLFSEFLQAINPIDS 331

  Fly   341 QAWKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFMH 405
            :.|..:....|:|.:::||..::..|.:|||||::.||||:|:||.:.:|:.|.:..::..:.:.
  Fly   332 EGWYLSGTCARILQILKAPVTLMLHLVVPLVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLV 396

  Fly   406 RKGNFLWYISLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCAT 470
            .|....:|:......|:   |.::|:|.|:.:..|:|||:||.||..:..:.::..:...::||.
  Fly   397 HKYAEWYYVPQFRMAIW---SLLVTMPLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWICAW 458

  Fly   471 EIDTVLEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTG 535
            |:|.::.:||.:..:..:||..|..:.:.....|.|...:|.|||.||||.:.||||.:::.|..
  Fly   459 EMDALISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNV 523

  Fly   536 NTVAYVRSLVGNRSEHHMEEYGE---IAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGLYVVY 597
            .....::..:.:|.:  :..||:   ..:|||.:.:.|.|.|..|..|.||||.||:...|:|::
  Fly   524 GIELVLQKKLNSRGQ--VVLYGDDGVTIYIFLVITITTTLWWCLTFNFVARRSAGLFMWSLFVLF 586

  Fly   598 LLFVTLVHEEVIHSFSDDIQVK 619
            |::.|.:..:.:|.|.|:||::
  Fly   587 LVYTTAIELQWVHGFQDNIQIR 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	34/100 (34%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	44/147 (30%)
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	53/146 (36%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	44/142 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450100
Domainoid	1	1.000	91	1.000	Domainoid score	I14182
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	P	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
	14	13.760