DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and CG12376

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster

Alignment Length:	617	Identity:	353/617 - (57%)
Similarity:	475/617 - (76%)	Gaps:	14/617 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VKNALDAEFDNFWKTVSCFAANNFPFEERCEFVQKAEDCNSSTNVIPYMRLLACDLKCINQFQEM 80
            |.||.||||||||.||||:|||.|||||||.||..|:|||.||||:||||::||||.|:|:|:::
  Fly     8 VPNAFDAEFDNFWDTVSCYAANTFPFEERCAFVASAKDCNRSTNVLPYMRIMACDLNCVNEFEQV 72

  Fly    81 IFIALFVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVE 145
            ||:|||:..|::||||||:..|.|||||||||||||.||||:|||||:||||:|||.|:|||||.
  Fly    73 IFLALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLASVN 137

  Fly   146 RHVPVFANNLSSALFVITISGGLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFALGY 210
            .:||||||:|::||||..:|||||.|.||||||:||:|||||||:..::|:.||..::.|..
  Fly   138 ANVPVFANSLAAALFVSMVSGGLICYTSPFKMNAYESVRDILFLIFGSMLLQYFLASSAHVP--- 199

  Fly   211 EFKFFIVLLVYISYIIINVADVYLLQKTIASTRTKMQKLLDEKQTPEIALKLQDLERKLEYYSQD 275
            |..|.::.||||.||::||.||||:::.:.:|..::..||..:.|||...:|.:|||....|::|
  Fly   200 ETSFIVMFLVYIFYILVNVVDVYLIRRALKTTNAQIDALLVGEMTPEKRKRLSELERNQAIYTRD 264

  Fly   276 TRVEILEKSSS-ISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDFFLALRPIK 339
            ..|||.|:::| .:|.:|||||:||.|:.|:|::|:.||.:..:....:|.|:|:|.|:|||||.
  Fly   265 MEVEIFERTNSGPNINKIRYTTLRMGRSTRISLDRKATRMVLHNRALGRNWGLFKDLFIALRPIN 329

  Fly   340 CQAWKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFM 404
            |:.|::..::.|..:|.:.|||:||.:||||||||::|||||||||.|.|::|||:||....:.:
  Fly   330 CEKWRKGNIIKRAFMLTKIPAVIICCIYIPLVDYELDKHGWNKLLNCIQVMLNPAMSIMAIKALL 394

  Fly   405 HRKGNFLWYISLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCA 469
            ..:||.|||:::....||...|..:|||.|||:...:||||||.||.|||:||||||||:||:||
  Fly   395 SSRGNSLWYVAMGEEAIYAMYSLPITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFMIFICA 459

  Fly   470 TEIDTVLEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVT 534
            ||||.||||||:||.::|::|||||||.||:||.|.||.|:|:||||:||:||||||.|||:|::
  Fly   460 TEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMS 524

  Fly   535 GNTVAYVRSLVG------NRSEHHMEEYGEIAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGL 593
            .:||.:|::|.|      |::.:    ||..||||||:.:|:.||||||||||||||:|::||..
  Fly   525 ASTVMHVKNLFGLPVSEANQTGN----YGLNAFIFLNLGVFSTLLWSTTLGFFARRSVGIFSIVF 585

  Fly   594 YVVYLLFVTLVHEEVIHSFSDDIQVKSAFGDI 625
            |.:||||..|:|.:||||||.|:.||:|||||
  Fly   586 YCIYLLFAILIHRKVIHSFSVDLPVKAAFGDI 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	71/99 (72%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	92/150 (61%)
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	315/565 (56%)
		Na_Ca_ex	85..219	CDD:279963	87/136 (64%)
		Na_Ca_ex	448..595	CDD:279963	92/150 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450096
Domainoid	1	1.000	91	1.000	Domainoid score	I14182
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	P	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
	14	13.760