DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and Slc24a5

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_038960915.1	Gene:	Slc24a5 / 311387	RGDID:	1310565	Length:	503	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	106/559 - (18%)
Similarity:	195/559 - (34%)	Gaps:	187/559 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VAFCFQILVLLIYTINV----YYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERH 147
            :...|.|.:.:...:::    |:.|:|:.:|..|.:::.:||.|.||.|:::.:.      |...
  Rat    71 IVIYFLITLYMFMAVSIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPEL------VTAF 129

  Fly   148 VPVFANNLSSALFVITISGGLIFYISPFKMNSYETVRDILFLLLAT-----LLMDYFAYTTNHFA 207
            :.||..  ...:.:.||.|..|     :.:........:|..:::|     |..|...|..:..|
  Rat   130 LGVFIT--KGDIGISTILGSAI-----YNLLGICAACGLLSNMVSTLSCWPLFRDCAVYAVSVGA 187

  Fly   208 L--------GYEFKFFIVLLVYISYIIINVADVYLLQKTIASTRTK--------MQKLLDEKQTP 256
            :        .|.::..::||:|..|:::...|.     ||:...||        :.|.::|:...
  Rat   188 VFGIIFDNRVYWYEGALLLLIYGLYVLLLCFDT-----TISRYVTKTCRPCCPCLAKAMEERSEQ 247

  Fly   257 EIALKLQDLERKLEYYSQDTRVEILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQ 321
            :..|.                   .|..|.|.|                   ||.:|.
  Rat   248 QTLLG-------------------WENESQIYI-------------------RRQSRT------- 267

  Fly   322 SKNQGIFRD------FFLALR--------PIKCQAWKQAELLNRVLLLIRAPAVVICTLYIPLVD 372
              :.|||::      ..|:|.        |....:..:|: |.|:..::..|.:.:..|..|
  Rat   268 --DSGIFQEDSGYSQLSLSLHGLSQVSEDPPSVFSMPEAD-LRRIFWVLSLPVITLLALTTP--- 326

  Fly   373 YEMEKHGWNKLLNAINVVVNPALSISIFLSFMHRKGNFLWYISLQNTLIYGASSFVLTVPFAVFI 437
             :..:..|.      |..|     |:.|:|        .::||        |.::||.
  Rat   327 -DCRRKLWK------NYFV-----ITFFMS--------AFWIS--------AFTYVLV------- 356

  Fly   438 LFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVIGNILSIDDNYMGATVKAFTGNLG 502
                         |:.||                       .|..|.|.|..||.|:.|...::.
  Rat   357 -------------WMVTI-----------------------TGETLGIPDTVMGLTLLAAGTSIP 385

  Fly   503 TLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGNTVAYVRSLVGNRS---EHHMEEYGEIAFIFL 564
            ...|:..||..|...||.::.:|.:.|.::..| ...::::...|.|   |.:.:....|. |.|
  Rat   386 DTVASVLVARKGKGDMAISNIVGSNVFDMLCLG-LPWFIKTAFTNASAPIEVNSKGLTYIT-ISL 448

  Fly   565 NMALFTILLWSTTLGFFARRSMGLYSIGLYVVYLLFVTL 603
            |:::|.:.|.....|:...|.:|:..:   |.||...||
  Rat   449 NISIFLLFLAVHFNGWKLDRKLGVVCL---VSYLGLATL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	20/102 (20%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	32/147 (22%)
Slc24a5	XP_038960915.1	2A1904	<20..>241	CDD:273344	37/187 (20%)
Slc24a5	XP_038960915.1	2A1904	<293..493	CDD:273344	55/272 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810