Protein Alignment CG5348 and SLC24A5

DIOPT Version :9

• Sequence 1: NP_611156.3
• Gene: CG5348 / 36877
• FlyBaseID: FBgn0034156
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_995322.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 500
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 116/592 - (19%)
• Similarity: 201/592 - (33%)
• Gaps: 213/592 - (35%)

  Fly    69 CDLKCINQFQEMIF---------IALFVAFCFQILVLLIYTINV----YYSPALKAVSRFLHMNE 120
            |.:...::|.|..|         |.::    |.|:|.:...|::    |:.|:|:.:|..|.:::
Human    46 CVISPSSEFPEGFFTRQERRDGGIIIY----FLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQ 106

  Fly   121 HLAGVTLMAFGNTSADFFANLASVERHVPVFANNLSSALFVITISGGLIFYI------SPFKMNS 179
            .:||.|.||.|:::.:.      |...:.||..  ...:.:.||.|..|:.:      .....|:
Human   107 DVAGTTFMAAGSSAPEL------VTAFLGVFIT--KGDIGISTILGSAIYNLLGICAACGLLSNT 163

  Fly   180 YETVRDILFLLLATLLMDYFAYTTNHFA-LG-------YEFKFFIVLLVYISYIIINVADV---- 232
            ..|      |....|..|..|||.:..| ||       |.::..::||:|..|:::...|:
Human   164 VST------LSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQ 222

  Fly   233 YLLQK--------TIASTRTKMQKLL---DEKQTPEIALKLQDLERKLEYYSQDTRVE--ILEKS 284
            |:::|        ..|..|::.|.|:   ||.|               .:..:.:|.:  |..:.
Human   223 YIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQ---------------PFIRRQSRTDSGIFYED 272

  Fly   285 SSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDFFLALRPIKCQAWKQAELL 349
            |..|...|....:..:.....||     .||                            .:|: |
Human   273 SGYSQLSISLHGLSQVSEDPPSV-----FNM----------------------------PEAD-L 303

  Fly   350 NRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFMHRKGNFLWYI 414
            .|:..::..|.:.:..|..|    :..|..|.      |..|     |:.|:|       .:|
Human   304 KRIFWVLSLPIITLLFLTTP----DCRKKFWK------NYFV-----ITFFMS-------AIW-- 344

  Fly   415 SLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVI 479
                   ..|.:::|.                    |:.||                       .
Human   345 -------ISAFTYILV--------------------WMVTI-----------------------T 359

  Fly   480 GNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFF------------TIV 532
            |..|.|.|..||.|:.|...::....|:..||..|...||.::.:|.:.|            |..
Human   360 GETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFIKTAF 424

  Fly   533 VTGNTVAYVRSLVGNRSEHHMEEYGEIAFIFLNMAL-FTILLWSTTLGFFARRSMGLYSIGLYVV 596
            :.|:..|.|.|    |...::.....|:.|||.:|: |.        |:...|.:|:..:   :.
Human   425 INGSAPAEVNS----RGLTYITISLNISIIFLFLAVHFN--------GWKLDRKLGIVCL---LS 474

  Fly   597 YLLFVTL 603
            ||...||
Human   475 YLGLATL 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	24/109 (22%)
		Na_Ca_ex	458..603	CDD:279963	33/157 (21%)
SLC24A5	NP_995322.1	Na_Ca_ex	<20..>224	CDD:332332	44/195 (23%)
		Na_Ca_ex	<290..490	CDD:332332	58/315 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810