DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and ncx-8

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_504341.1	Gene:	ncx-8 / 182575	WormBaseID:	WBGene00003573	Length:	703	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	144/708 - (20%)
Similarity:	274/708 - (38%)	Gaps:	147/708 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DVFTVKNALDAE-FDNFWKTVSCFAAN------NFPFEERCEFVQKAEDCNSSTNVIPYMRLLAC 69
            |..|:..|.:|. :|....|....||:      .:..||:|.:::..:|.......:.:...:.|
Worm    30 DYPTITMARNASMYDGMPFTAEMCAASECELHKGWTSEEKCAYIKCNQDSCEGGGYLTWSHYVKC 94

  Fly    70 DLKCINQFQEMIFIALFVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTS 134
            .   .|....::.|.:.:.:...:.|::....:.::.|::..:...|.|:|.:||||.:||||.:
Worm    95 Q---YNIGARVVLIIVGIIYLIFLFVVMSTIADDFFCPSISGIVTHLKMSESIAGVTFLAFGNGA 156

  Fly   135 ADFFANLASV-----ERHVPVFANNLSSALFVITISGGLIFYISPFKMNSYETVRDILFLLLATL 194
            .|.|.:::||     .:......:...:::||.|:...:|.:...||:....|:||::|.::.
Worm   157 PDVFGSISSVLSTPKPKAALALGDLFGTSIFVTTVVLAIIIFTKSFKVAIIPTLRDLIFYMIT-- 219

  Fly   195 LMDYFAYTTNHFALGYEFKFFIVLLVYISYIIINVADVYLLQK---TIASTR---TKMQKLLDEK 253
                .|:.|      :.|..|..:.|::....:.:..||||..   :|..||   .|.:|.|:.:
Worm   220 ----LAFIT------FCFLKFDKIEVWMPATFLGIYAVYLLTVIAFSIYRTRRKNLKKKKQLESE 274

  Fly   254 QTPEIALK-----------LQDLERKLEYYSQDTRVEILEKSSSISITRIRYTTMRMIRNPRVS- 306
            :..|.|:.           .:.||:|.|..|..|...::...|.......|...::.|.|.:..
Worm   275 KDDESAISRPESVASNMPICEKLEKKTESMSVSTLFHVMVGLSRFMKKLNRTNKIQSIENKKQGF 339

  Fly   307 VNRRYTRNMKLD-YTQSKNQGI------------------------------------------- 327
            ||..::.::..| .|..:|:.|
Worm   340 VNEGFSESLDADELTLKRNRMISLIFRNKTLDTDLESMKTLDEMESSDDEGREEEFAYAHHTVFT 404

  Fly   328 -------------FR------------DFFLALRPIKCQAWKQAE------LLNRVLLLIRAPAV 361
                         ||            |....|:|     |...|      :..:::::||....
Worm   405 SHDQMSLAATEFEFRELTTWRSRDWIIDLLYHLKP-----WPSREEFSEMNIFVKIIMIIRIIPS 464

  Fly   362 VICTLYIPLVDYEMEKHGWNK---LLNAINVVVNPALSISI--FLSFMHRKGNFLWYISLQNTLI 421
            ....:.||  ..||   .|.|   ||:....:.....||.|  ...|....|.:|:.::...|:.
Worm   465 FFMKMTIP--SNEM---SWCKPLFLLHCFASIQFALFSIQIINLKPFDGSPGLWLYGLAFSATIA 524

  Fly   422 YGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATEIDTVLEVIGNILSID 486
            ..|..|   :|....:.:|..         |::.:....|:..|:..|.||.:|:.::|.:..:.
Worm   525 LLALCF---LPLNKELKYHKE---------VYSYLGFLMSIAWIYATANEIISVMTMVGVVTGLS 577

  Fly   487 DNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGNTVAYVRSLVGNRSEH 551
            ...:|.||.:::..:|.:.|:.||...||||||.|:||||..|.:::.......:.|..|.:.:.
Worm   578 QELLGLTVMSWSDCIGDIVADIAVIKQGYPKMAMAAAIGGPLFNLLIGFGLPFTIASAQGKQIDL 642

  Fly   552 HMEEYGEIAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGLYVVYLLFVTLVHEEVI 609
            .:.....|..:||.::|.|..:......|..|....:..|.:::.:::||.|....|:
Worm   643 IINPVYRILLLFLGISLVTTFVALFIERFTVRWPHAVALIFIFINFVIFVCLAEFHVL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	25/104 (24%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	38/144 (26%)
ncx-8	NP_504341.1	PLN03151	61..628	CDD:215604	122/603 (20%)
		Na_Ca_ex	107..253	CDD:279963	36/157 (23%)
		Na_Ca_ex	544..681	CDD:279963	35/136 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165703
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.720