DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and ncx-6

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_499146.2	Gene:	ncx-6 / 182354	WormBaseID:	WBGene00003571	Length:	590	Species:	Caenorhabditis elegans

Alignment Length:	594	Identity:	132/594 - (22%)
Similarity:	256/594 - (43%)	Gaps:	100/594 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CEFVQKAEDCNSSTNVIPYMRLLACDLKCINQFQEMIFIALFVAFCFQILVLLIYTINV---YYS 106
            ||:|:..:|.......:.:.|.:.|      .....:.|.|.:.....:|||.|...:.   ::|
Worm    65 CEYVKCNDDNCEGGGYVLWTRYVEC------ASSPAVRIILIITGVIYMLVLFIMVSSAADDFFS 123

  Fly   107 PALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASV-ERHVP----VFANNLSSALFVITISG 166
            |::.::...|.::|.:||||.|||||.:.|.|..:||| ....|    .......:.|||.|:..
Worm   124 PSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSPTPKADLALGELFGAGLFVTTMVL 188

  Fly   167 GLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFALGYEFKFFIVLLVYISYIIINVAD 231
            .:..:..|||...:.::|||.|.|:|...:.:.....:|..:.....|..|.|:|:..:|::
Worm   189 AVTIFTRPFKAEVFSSIRDIAFYLVALAFLAFCFVYYDHVEIWMPITFLGVYLIYVCTVILS--- 250

  Fly   232 VYLLQKTIASTRTKMQKLLDEKQTPEIALKLQDLERKLE-----YYSQDTRV----EILEKSSSI 287
                  .|...|.|.    ||::..|:  |..|.: .||     |.|....|    |:::..:.|
Worm   251 ------QILHNRHKK----DEEKVDEV--KTVDTD-SLEDDDDIYVSHGHHVLHAHEVMKMEAEI 302

  Fly   288 -SITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFRDFFLALRP-IKCQAWKQAELLN 350
             ::..::..:.|                           |:..||...|:| .....|.:..:..
Worm   303 EAVEPLKTWSFR---------------------------GVVHDFKEHLKPWPSMDEWDEMNIFQ 340

  Fly   351 RVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFMHRKGNFLWYIS 415
            :|:.::......:..|.||     ..:..|:|.:..:..::.|     :||.|..:..:...:.:
Worm   341 KVIAVLNTIPNFLFKLTIP-----HSEQPWSKPITLLQCLICP-----VFLLFCIQVCSISPFPN 395

  Fly   416 LQNTLIYGASSFVLTVPFAVFILFHARTDV---PPSYHWVFTIMNLTGSMFLIFLCATEIDTVLE 477
            .....:||   .:|:|.....:||.  |::   ||.|..:.:......|:..|:|.::|:..|:.
Worm   396 SPGLWMYG---LILSVLLTAAVLFF--TELHKEPPFYKSLISYAGFLMSIAWIYLISSEVVNVVT 455

  Fly   478 VIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGN---TVA 539
            ::|.:..:....:|.|:.|::.::|.|.|:.:||..|||:||.|:||||..|.:::...   |:|
Worm   456 MLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGLPFTIA 520

  Fly   540 YVR----SLVGNRSEHHMEEYGEIAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGLYVVYLLF 600
            .::    |::.|.:...:..:..|:.||..:|:|       ...:|.||......:.:|:.:.:|
Worm   521 KIQGKSISMIINPTYRLLMLFLAISLIFTLIAMF-------AQKYFLRRIHSYSLVFIYISFFVF 578

  Fly   601 VTLVHEEVI 609
            :.|..::::
Worm   579 IGLSLDDIL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	31/107 (29%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	39/151 (26%)
ncx-6	NP_499146.2	Na_Ca_ex	105..249	CDD:279963	41/143 (29%)
ncx-6	NP_499146.2	Na_Ca_ex	431..579	CDD:279963	38/154 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165712
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.720